Acute pancreatitis (AP), especially severe acute pancreatitis often causes extra-pancreatic complications, such as acute gastrointestinal mucosal lesion (AGML) which is accompanied by a considerably high mortality, yet the pathogenesis of AP-induced AGML is still not fully understood. In this report, we investigated the alterations of serum components and gastric endocrine and exocrine function...

We set up a new model of gastric bleeding induced by the luminal perfusion of aspirin (ASA) in rats pretreated with clopidogrel under conditions where acid secretion is stimulated, and examined the effect of antiulcer drugs on the bleeding. Under urethane anesthesia, acid secretion was stimulated by i.v. infusion of histamine (8 mg/kg/h), and two catheters were inserted into the stomach, one fr...

Statement of problem: Aspirin is extensively used as an analgesic, antipyretic, anti-thrombotic and antiinflammatory drug. It is safe in therapeutic doses but it is toxic in over dosage or in chronic injudicious use, when it causes acute or chronic toxicity respectively. Acute toxicity causes gastric ulceration and bleeding. Gastric ulcer developed when the imbalance occurs between aggressive a...

A role of IL-18 in the induction of gastric lesions by water immersion and restraint stress (WRS) was investigated. When wild-type BALB/c mice were exposed to WRS, levels of IL-18 in the serum and stomach increased rapidly with the development of acute gastric lesions. In IL-18-deficient mice [IL-18 knockout (KO) mice] similarly exposed to WRS, no gastric lesions were observed, but the administ...

BACKGROUND The cholinergic anti-inflammatory pathway is an endogenous mechanism by which the autonomic nervous system attenuates macrophage activation via nicotinic acetylcholine receptors (nAChR). This concept has however not been demonstrated at a cellular level in intact tissue. To this end, we have studied the effect of nicotine on the activation of resident macrophages in a mouse stomach p...

Several conditions associated with reduced gastric acid secretion confer an altered risk of developing a gastric malignancy. Helicobacter pylori-induced atrophic gastritis predisposes to gastric adenocarcinoma, autoimmune atrophic gastritis is a precursor of type I gastric neuroendocrine tumours, whereas proton pump inhibitor (PPI) use does not affect stomach cancer risk. We hypothesised that e...

In this study we tested the genotoxicity of two widely used phenolic antioxidants, butylated hydroxyanisole (BHA) and tert-butylhydroquinone (TBHQ) in multiple mouse organs using the alkaline comet assay. Tissue samples from four organs (stomach, liver, kidney and bone marrow) were collected from male mice at 3 and 24 h post treatment with BHA (800 mg/kg) or TBHQ (400 mg/kg) and examined for ge...

H. pylori is a human pathogen that colonizes the epithelium of the stomach. The host immune response may influence the disease process, where cytokines play important roles in the development of disease. In this study, the concentrations of selected cytokines in the gastric antrum and stomach body mucosa and also in the serum were evaluated. Eighty patients according to their rapid urease test ...

breathomics is the metabolomics study of exhaled air. it is a powerful emerging metabolomics research field that mainly focuses onhealth-related volatile organic compounds (vocs). since the quantity of these compounds varies with health status, breathomics assuresto deliver noninvasive diagnostic tools. thus, the main aim of breathomics is to discover patterns of vocs related to abnormal metabo...

We investigated inhibitory effects of extract containing quercetin-3-O-β-D-glucuronopyranoside (ECQ) extracted from Rumex Aquaticus Herba on indomethacin-induced gastric damage in Rats. Gastritis was induced in male Sprague-Dawley rats (200~220 g) by oral administration of indomethacin at a dose of 40 mg/kg. One hour before administration of indomethacin, animals were orally pretreated with ECQ...