Guillain-Barre syndrome (GBS) is an eponym for a heterogeneous group of immune-mediated peripheral neuropathies. We describe a case of GBS in a patient who recieved intravenous streptokinase therapy for acute anterior myocardial infarction. Clinical symptoms are thought to result from streptokinase-antibody complex mediated damage to the local blood-nerve barrier. Patient was treated with 5-day...

' Reid HA, Nkrumah FK. Fibrin degradation products in cerebral malaria. Lancet 1972;i:218-21. 2 Jaroonkesama N. Intravascular coagulation in falciparum malaria. Lancet 1972;i :221-3. 3Preston FE, Edwards IR. The successful use of streptokinase in a patient with purpura fulminans. Br MedJ 1973;iii :329-30. 4 Martindale W. Streptokinase. Extra Pharmacopoeia, 27th ed. London: Pharmaceutical Press,...

Streptokinase is a fibrinolytic agent that enhances plasmin activation and is used in selected patients with acute ST elevation myocardial infarction (STEMI). Similar to the other thrombolytics, a common side effect is bleeding, especially from venous puncture sites. Here, we present a case of acute anterior wall STEMI complicated by large spontaneous iliopsoas hematoma after streptokinase admi...

17 ± 2.7 1.9 ± 0.4 5.9 ± 0.7 89 ± 28 Van Acker et al. (1) reported the presence of macro-LDH in serum 10 days after administration of streptokinase in the very acute phase of an acute myocardial infarction (AM!). They claimed a causal relationship between the finding of macro-LDH and administered streptokinase. However, a relationship with AM! itself, or its underlying cause, is not to be exclu...

The addition of plasminogen and streptokinase to rabbit serum results in appearance of chemotactic activity which is relatively heat-labile and dialyzable. Generation of this activity requires heat-labile factors in serum, but not the sixth component of complement. The optimal mole ratio for generation of chemotactic activity is 1:1 to 1:3 for plasminogen to streptokinase. Neither material alon...

Sixteen patients underwent emergency coronary artery bypass surgery immediately after intracoronary streptokinase infusion for acute evolving myocardial infarction. Of these, 11 patients had 70% residual stenosis in the recanalised vessel, and in five thrombolysis was unsuccessful. There were no hospital deaths. All the patients sustained myocardial necrosis, the peak activity of creatine phosp...

Recombinant desulfatohirudin (HI), a potent and specific thrombin inhibitor, was compared with heparin (HE) as an adjunct to streptokinase thrombolysis. In pentobarbital-anesthetized dogs, an occlusive thrombus (whole blood+thrombin) was introduced into the left anterior descending coronary artery (LAD) with superimposed endothelial damage and distal high-grade stenosis. Intravenous infusion of...

The introduction by Cathie (1) of intrathecal streptokinase to prevent and treat blockage of the cerebrospinal pathways led to hopes that the treatment of this serious complication might be greatly improved; and that prevention and removal of the exudate in this disease might shorten the course of treatment and render chemotherapy more effective. These hopes were sustained by later reports (2, ...