Introduction: Atherothrombotic diseases such as myocardial or cerebral infarction are serious consequences of the thrombus formation in blood vessels. Thrombolytic agents are used to dissolve the already formed clots in the blood vessels. However, these drugs have certain adverse effects, which cause serious and sometimes fatal consequences. Methods: Plants essential oils were prepared and ...

A simple screening method for determining the fibrinolytic activity of plasma is described. A streptokinase activated system is used, which measures the result of the interplay of all components of the fibrinolytic system with the exception of activators, which are added in excess. Mean lysis time and standard deviation with this method is 6.9 +/- 1.4 min. The sensitivity of the method in detec...

Cardiovascular diseases (CVDs) are one of the major causes death in world. Medicinal plants with thrombolytic properties may be used as an alternative to modern medicines for CVDs. The present study was aimed evaluate potential six medicinal available Bangladesh using vitro clot lysis method where streptokinase and ethanol were a positive negative control, respectively. Ethanolic extract at dos...

Thrombolytic therapy has become standard care in treating acute myocardial infarction. Fibrinolytic drugs such as streptokinase, APSAC and urokinase are non fibrin specific, and induce systemic activation of the fibrinolytic process, while t-PA and prourokinase are fibrin specific since they are able to activate mainly fibrin bound plasminogen. Both groups of thrombolytics exert different and o...

BACKGROUND Streptokinase reduces the incidence of left ventricular thrombosis after acute myocardial infarction. However, it is unknown whether a similar effect can be obtained with different thrombolytic agents and whether subcutaneous calcium heparin can have an additional efficacy. METHODS AND RESULTS To compare the effects of two different thrombolytic agents combined or not with heparin ...

With the availability of a method of purifying plasminogen from human Fraction IIL8 the therapeutic use of this enzyme in thrombotic conditions became a distinct possibility. Before attempting the clinical use of purified plasminogen, however, it appeared advisable to investigate the reporte that the enzyme responsible for the fibrinolytic activity can be separated from the agent producing prot...

Rice chaff (Variety: Devamallige) is used as the substrate for the production of fibrinolytic enzyme by Penicilliumchrysogenum AGSF16 in solid state fermentation. The optimized moisture content of the medium is 35-45 %( v/w) an inoculumof 5-10% (v/v) and an average particle size of 400μm of the substrate were optimum for productivity and enzyme activity of 65-70 IU per ml filtrate was achieved ...

BACKGROUND AND PURPOSE We used 99mTc-hexamethylpropyleneamine oxime single-photon emission computed tomography (SPECT) to study cerebral perfusion in patients treated with streptokinase for acute ischemic stroke in an open and prospective study. Our primary aims were (1) to compare the extent of reperfusion between patients who had received thrombolytic therapy and a control group studied durin...

In cooperation with a group of general practitioners (GP), we investigated the possible risk and benefit of prehospital initiation of thrombolytic therapy in acute myocardial infarction (AMI) with anisoylated plasminogen streptokinase activator complex (APSAC) at the patient's home. During a 14-month period, 58 patients with suspected AMI were evaluated by their GP using a protocol with strict ...

BACKGROUND QT dispersion (QTd) is equal to longer QTc minus shorter QTc measured by 12-lead electrocardiogram (ECG). QTd reflects inhomogeneity in repolarization of ventricular myocardium and because of easy and fast measurement of QTd, it can be used to predict high-risk patients for dysrhythmia after Acute Myocardial Infarction (AMI). OBJECTIVES This study aimed to assess the effect of thro...