patients treated with streptokinase, one of seven treated with Arvin, and two of seven given heparin. Streptokinase was shown to cause extensive dissolution of thrombi in all but two of the 12 patients studied, sometimes within 12 hours but in one patient not until after six days of continuous infusion. Methods and aims of laboratory control were discussed (Kakkar et al, 1969) and the side effe...

Streptococcus pyogenes is one of the most frequent human pathogens. Recent studies have identified dendritic cells (DCs) as important contributors to host defense against S. pyogenes. The objective of this study was to identify the receptors involved in immune recognition of S. pyogenes by DCs. To determine whether Toll-like receptors (TLRs) were involved in DC sensing of S. pyogenes, we evalua...

BACKGROUND Streptococcus pyogenes (S. pyogenes) causes various serious diseases including necrotizing fasciitis and streptococcal toxic shock syndrome. One serious problem observed recently with S. pyogenes therapy is attenuation of the antibiotic effect, especially penicillin treatment failure and macrolide resistance. Hainosankyuto, a traditional Japanese medicine based on ancient Chinese med...

Streptokinase is a potent fibrinolytic agent which is widely used in treatment of deep vein thrombosis (DVT), pulmonary embolism (PE) and acute myocardial infarction (MI). Major limitation of this enzyme is its short biological half-life in the blood stream. Our previous report showed that complexing streptokinase with chitosan could be a solution to overcome this limitation. The aim of this re...

Streptokinase is a potent fibrinolytic agent which is widely used in treatment of deep vein thrombosis (DVT), pulmonary embolism (PE) and acute myocardial infarction (MI). Major limitation of this enzyme is its short biological half-life in the blood stream. Our previous report showed that complexing streptokinase with chitosan could be a solution to overcome this limitation. The aim of this re...

In this present study, the bark extracts of Erythrina variegate were subjected to evaluate of the thrombolytic activity, which was assessed by using human erythrocyte and the results were compared with standard streptokinase (SK). The methanol extract showed 72.14 ± 3.77 % clot lysis as compared to 78.42 ± 1.6 % clot lysis produced by standard streptokinase.

BACKGROUND In acute myocardial infarction patients who do not reperfuse their infarct arteries shortly after thrombolytic treatment have a high morbidity and mortality. Management of this high risk group remains problematic, especially in centres without access to interventional cardiology. Additional thrombolytic treatment may result in reperfusion and improved left ventricular function. MET...

A. AMERY, J. VERMYLEN, AND M. VERSTRAETE (Leuven University, Belgium) This study compares the effect on fibrinogen and plasminogen levels of the infusion of a high (1,200,000 units) and medium (250,000 units) standardized initial dose of streptokinase. In both groups the administration of the initial dose was followed by a continuous infusion of 100,000 units of streptokinase per hour. Immediat...