BACKGROUND Actinomycetes are saprophytic soil bacteria, and a rich source of industrial enzymes. While some of these enzymes can be produced using well-characterized production platforms such as Escherichia coli or Bacillus subtilis, Streptomyces lividans may be the preferred host for proper folding and efficient secretion of active enzymes. A combination of promoters, signal peptides and hosts...

Streptomyces has been known to form two types of septa. The data in this research demonstrated that Streptomyces griseus forms another type of septum near the base of sporogenic hyphae (basal septum). To understand the regulation of the septation machinery in S. griseus, we investigated the expression of the ftsZ gene. S1 nuclease protection assays revealed that four ftsZ transcripts were diffe...

The production of streptomycin is limited mostly to a few strains of Streptomyces griseus (Schatz, Bugie, and Waksman, 1944; Waksman, Reilly, and Johnstone, 1946; Carvajal, 1946a and b) and to Streptomyces bikiniensis (Johnstone and Waksman, 1948). Trussell, Fulton, and Grant (1947) examined a strain of Streptomyces which appeared to produce both streptomycin and streptothricin. Although this o...