Objective(s): Broad range of metabolic changes associated with highly active antiretroviral therapy (HAART) has been reported over decades including reproductive perturbations. The current study aimed at investigating the role of Hypoxis hemerocallidea (Hyp) in the seminal and morphometric alterations in the testes of streptozotocin-nicotinamide-induced diabetic rats under HAART.Materials and M...

Context: Gestational diabetes is defined as carbohydrate intolerance with onset or first recognition during pregnancy. Diabetes during pregnancy increases the incidences of congenital anomalies, in a mother and her embryo. Oxidative stress has been implicated to be responsible in diabetic embryopathy. Objective: In this study, we used nanoceria as an antioxidant for amelioration of diabetic embry...

Introduction: Diabetes drastically increases the risk of developing reproductive system disorders. The aim of this study was to investigate the effect of Citrullus Colocynthis pulp on testosterone and LH levels in streptozotocin-induced diabetic rats. Methods: Thirty-two male Wistar rats were divided into four groups as follows (n = 8 in each group): 1) normal, 2) pulp, 3) diabetic, and 4) ...

BACKGROUND Ceiba pentandra (L.) Gaertn, commonly called silk-cotton tree, has been extensively used by traditional medicine practitioners in Northern and Eastern Nigeria in the control and management of diabetes. OBJECTIVE To evaluate the hypoglycaemic and anti-hyperglycaemic effect of ethanolic extract of Ceiba pentandra bark in normal and streptozotocin induced diabetic rats. METHOD Scree...

Objective(s):Painful diabetic neuropathy is associated with hyperexcitability and hyperactivity of spinal cord neurons. However, its underlying pathophysiological mechanisms have not been fully clarified. Induction of excitatory/inhibitory neurotransmission imbalance at the spinal cord seems to account for the abnormal neuronal activity in diabetes. Protective properties of neurosteroids have b...

Abstract: Aim: This study aimed to establish the dose of streptozotocin required induce Type -1 diabetes in Wistar rats. Background: Streptozotocin is currently employed worldwide insulin-dependent mellitus also known as 1 experimental animals. Though many reports on use induction are reported literature, they were not reproducible. Moreover, there was no mention mortality associated with same ...

The pathophysiological processes underlying the development of diabetic osteopenia has not hitherto been elucidated. Induction of streptozotocin diabetes leads in our experiments to decrease of bone density, ash, mineral content and to thinner cortical width compared to control male rats. In order to investigate the pathogenetic role of bone resorption by osteoclasts in streptozotocin-induced d...

. AbstrAct Complications of diabetes mellitus that affect the different body organs represent an increasing threat because of the increasing prevalence of this condition worldwide. As rodent incisors are continuously growing teeth that include all stages of amelogenesis, they could be used as a model for the effect of diabetes on tooth development. In the present experimental study, we analyzed...