Only 23% of women will begin a successful pregnancy during the first menstrual cycle in their attempt to conceive. A large number of these failed reproductive attempts are attributed to a broad set of pathologies, but across studies an important proportion of unsuccessful cycles is consistently left unexplained. Stress has become a commonly cited factor when discussing unexplained reproductive ...

Chronic stress has been shown to alter behaviour in both humans and rodents. For example, previous studies have shown that chronic stress can impair skilled motor function in animals. The stress response is defined by an increase in stress hormones, cortisol in humans and corticosterone (CORT) in rodents, both secreted by adrenal glands. CORT can cross the blood brain barrier easily to regulate...

RATIONALE Tribbles (TRB)3 is an intracellular pseudokinase that modulates the activity of several signal transduction cascades. TRB3 has been reported to inhibit the activity of Akt protein kinases. TRB3 gene expression is highly regulated in many cell types, and amino acid starvation, hypoxia, or endoplasmic reticulum (ER) stress promotes TRB3 expression in noncardiac cells. OBJECTIVE The ob...

BACKGROUND Premenstrual syndrome is a psychoneuro endocrine stress related disorder. PURPOSE To study the effect of premenstrual stress on autonomic function. METHODS Study of autonomic function basal heart rate, basal blood pressure, systolic & diastolic response to cold stimulus was carried out in 80 Eumenorrheic females age between 18-25 yrs. during premenstrual & post menstrual phase. S...

This overview introduces the contributions in this Special Issue with the aim of presenting an integrated picture of it. The contributions cover several important areas: protein stability and function under extreme conditions, osmotic stress and osmoadaptation, the structural features of the cell membrane and their possible significance with regard to heat stress, the molecular chaperone machin...

Objective: The antiapoptotic effect of p21 (p21) was examined in human umbilical vein endothelial cells (HUVEC) exposed to laminar shear stress (SS) or to the nitric oxide donor sodium nitroprusside (SNP) and in a mouse model of hindlimb ischemia.Methods: In vitro: Cells were cultured without serum and in the presence of cobalt chloride to simulate hypoxia for 12 h (T0). Shear stress was applie...

Introduction: During hemorrhagic shock (HS), the kidneys are one of the primary target organs involved. Oxidative stress is shown to be enhanced in different models of acute kidney injury (AKI). Remote ischemic preconditioning (RPC) by brief limb ischemia is considered to be a safe method to protect different organs from further damage. In this study, we investigated the effects of brief hind l...

Inappropriate responsiveness of the stress system may cause numerous alterations in endocrine, metabolic and autonomic systems. Many studies have been carried out on the effects of acute stress on thyroid function but the effects of chronic stress have not been fully investigated. The purpose of this study is to evaluate the effects of long term handling stress on thyroid function. Study was pe...

Correct estimation of water inflow into underground excavations can decrease safety risks and associated costs. Researchers have proposed different methods to asses this value. It has been proved that water transmissivity of a rock joint is a function of factors, such as normal stress, joint roughness and its size and water pressure therefore, a laboratory setup was proposed to quantitatively m...