background: psoriasis is a common chronic and relapsing skin disease with unknown etiology being observed at any age and any gender, having a 1. 5-3% prevalence rate among the general population. psoriatic lesions consist of pruritic and scaling papules, residing on an erythematous base, which are more commonly found on the scalp, extensor surfaces, palms and soles, and the nails. the conventio...

coronary artery disease is the leading cause of death worldwide. in this study, we compared two surgical methods of left internal mammary artery (lima) anastomosis on left anterior descending (lad) artery in patients with severe diffuse lesions. a total of 40 patients were included in our study and randomly assigned into two groups. in group a, after a long arteriotomy on lad, the posterior sur...

this paper introduces a novel methodology for the segmentation of brain ms lesions in mri volumes using a new clustering algorithm named scpfcm.  scpfcm uses membership, typicality and spatial information to cluster each voxel. the proposed method relies on an initial segmentation of ms lesions in t1-w and t2-w images by applying scpfcm algorithm, and the t1 image is then used as a mask and is ...

N(1)-meA and N(3)-meC are cytotoxic DNA base methylation lesions that can accumulate in the genomes of various organisms in the presence of S(N)2 type methylating agents. We report here the structural characterization of these base lesions in duplex DNA using a cross-linked protein-DNA crystallization system. The crystal structure of N(1)-meA:T pair shows an unambiguous Hoogsteen base pair with...

INTRODUCTION The present review serves to provide a concise overview of the current knowledge on therapeutic strategies with regard to fibrostenotic lesions in Crohn's disease. METHODS A literature search was performed focusing on the last 5 years, and current concepts of pathophysiology, epidemiology, and treatment have been summarized. RESULTS Fibrostenotic lesions in Crohn's disease are ...

Tirapazamine is a bioreductively activated DNA-damaging agent that selectively kills the hypoxic cells found in solid tumors. This compound shows clinical promise and is currently being examined in a variety of clinical trials, including several phase III studies. It is well established that DNA is an important cellular target for tirapazamine; however, the structural nature of the DNA damage i...

Certain matrix metalloproteinases (MMP) are expressed within the fibrous areas surrounding acellular lipid cores of atherosclerotic plaques, suggesting that these proteinases degrade matrix proteins within these areas and weaken the structural integrity of the lesion. We report that matrilysin and macrophage metalloelastase, two broad-acting MMPs, were expressed in human atherosclerotic lesions...

BACKGROUND Previous studies have reported white matter (WM) brain alterations in asymptomatic patients with human immunodeficiency virus (HIV). METHODS We compared diffusion tensor imaging (DTI) derived WM fractional anisotropy (FA) between HIV-patients with and without mild macroscopic brain lesions determined using standard magnetic resonance imaging (MRI). We furthermore investigated wheth...

BACKGROUND AND PURPOSE Magnetic susceptibility measured with quantitative susceptibility mapping has been proposed as a biomarker for demyelination and inflammation in patients with MS, but investigations have mostly been on white matter lesions. A detailed characterization of cortical lesions has not been performed. The purpose of this study was to evaluate magnetic susceptibility in both cort...

Cases are presented in which cerebral disease was associated with schizophrenic-like or manic-depressivelike psychoses, anxiety or obsessional states i.e. psychiatric disorders usually classed as 'functional'. Evidence is presented to suggest that this association is not due to chance. The cerebral structural changes are characterized either by the presence of 'focal' lesions, e.g. multiple scl...