The mycotoxin, citrinin (CTN), is a contaminant of various food and feed materials. Several in vivo and in vitro studies have demonstrated that CTN has broad toxicity spectra; however, dermal toxicity is not known. In the present investigation, dermal exposure to CTN was undertaken to study oxidative stress, DNA damage, cell cycle arrest, and apoptosis in mouse skin. A single topical applicatio...

The freshwater fish, Channa gachua was exposed to sub-lethal concentrations of an organophosphorus pesticide, monocrotophos. The fish was exposed to acute toxicity of monocrotophos for 16, 24 and 48 hours while for chronic toxicity it was exposed for 15, 30 and 45 days. The monocrotophos was found to be toxic to the fish, which was found to be increasing with the increase of its concentration. ...

Exposure of the scrotal skin to a concentrated paraquat solution led to renal and respiratory failure and to hepatic damage with eventual recovery of the patient. Dermal exposure to paraquat, especially to the scrotum may produce serious systemic toxicity.

The acute oral and dermal toxicity of two new ethyl-carbamates (ethyl-4-bromophenyl-carbamate and ethyl-4-chlorophenyl-carbamate) with ixodicide activity was determined in rats. The oral LD50 of each carbamate was 300 to 2000 mg/kg, and the dermal LD50 of each carbamate was >5000 mg/kg. Clinically, the surviving rats that had received oral doses of each carbamate showed decreased weight gain (P...

A 12 year old boy suffering from p67-phox deficient chronic granulomatous disease presented with a bullous skin disease and a lung infection with paecilomyces species. The histopathology of a bullous lesion showed subepidermal blister formation and microabcesses containing eosinophils in the dermal papillae. By direct immunofluorescence, linear staining of IgA at the dermal-epidermal junction w...