OBJECTIVE To test the effect of oral contraceptives (OCs) in combination with interferon β (IFN-β) on disease activity in patients with relapsing-remitting multiple sclerosis (RRMS). METHODS One hundred fifty women with RRMS were randomized in a 1:1:1 ratio to receive IFN-β-1a subcutaneously (SC) only (group 1), IFN-β-1a SC plus ethinylstradiol 20 μg and desogestrel 150 μg (group 2), or IFN-β...

Nitrous oxide (N2O) abuse induces vitamin B12 deficiency, resulting in complications the central and peripheral nervous systems. Some cases related to subacute combined degeneration or myeloneuropathy after N2O have been reported. However, isolated polyneuropathy without spinal cord involvement has rarely reported South Korea. We describe a 29-year-old woman who had inhaled “happy balloons” dai...

Parenchymatous cortical cerebellar atrophy (chronic atrophy of Purkinje’s cells). By Harry L. Parker (Section on Neurology) and James W. Kernohan (Section on Pathological Anatomy). From the Mayo Clinic, Rochester, Minnesota. Brain 1933; 56: 191–212. With Subacute spino-cerebellar degeneration occurring in elderly patients. By J. G. Greenfield. From the National Hospital, Queen Square, London. B...

In England Ogilvie (1941), Field (1949) and Conway (1952) have collected cases of childhood bronchiectasis over the long term and on the large scale needed for worthwhile information. The gloomy prognostication, based on old clinical and necropsy studies, that the bronchiectatic child will not grow up or will be a burden to himself and his neighbours, is not generally true. Since 1926-that is, ...

The neuropsychiatric states of 50 patients with vitamin B12 deficiency and 34 patients with folate deficiency presenting with megaloblastosis in a general hospital were examined and compared. Abnormalities of the nervous system were found in two-thirds of both groups. Peripheral neuropathy was the most common condition associated with vitamin B12 deficiency and affective disorder with folate de...

ALEXANDRU TOMESCU1, RENATA-MARIA SUMALAN1, GEORGETA POP1, ERSILIA ALEXA1, MARIANA-ATENA POIANA1, DANA-MARIA COPOLOVICI2, CRISTIANA SORINA STROE MIHAI4, MONICA NEGREA1, ATENA GALUSCAN3* 1Banat‘s University of Agricultural Science and Veterinary Medicine“King Michael I of Romania” from Timisoara, 119 Calea Aradului, 300645, Timisoara, Romania. 2Aurel Vlaicu University, 77 Revolutiei Blv, 310130, ...

Nitrous oxide is increasingly being used as a recreational drug. Prolonged use of nitrous oxide can have disabling neurological sequelae due to functional inactivation of vitamin B₁₂. We present three cases illustrating the neurological complications of using nitrous oxide. Two of these patients received nitrous oxide as a consequence of repeated hospital attendance and the third via 'Whippit' ...

Cobalamin-dependent methionine synthase catalyzes the transfer of a methyl group from N5-methyltetrahydrofolate to homocysteine, producing tetrahydrofolate and methionine. Insufficient availability of cobalamin, or inhibition of methionine synthase by exposure to nitrous oxide, leads to diminished activity of this enzyme. In humans, severe inhibition of methionine synthase results in the develo...

CONTENTS. Page The Projection of the Olfactoury Epithelium on the Olfactory Bulb in the Rabbit.' W. E. LeGrosClark Observations on the Passage of Weed's Prussian Blue Mixture along the Axids Cylinders and Inter-Fibre Fluid of Nerves. E. J. Field. A Method of Measuring Reflex Times Applied in Sciatica and,-Other Conditions due to Nerve-Root Compression. Donald S. Malcolm 15 Arteriography and Car...