An association between sarcoidosis and neoplasia has been suggested. The development of malignant lymphoma has been reported in several patients with sarcoidosis,2 but there have been few reports of patients with sarcoidosis and multiple myeloma.24 We describe five patients with sarcoidosis who developed multiple myeloma. Case histories The table shows details offive patients with sarcoidosis s...

BACKGROUND Preliminary data show that endosonography guided fine needle aspiration (EUS-FNA) may be an accurate method for diagnosing sarcoidosis. However, these data were obtained in a small selected group of patients with a very high pretest probability of sarcoidosis. This retrospective study reports on the use of EUS-FNA in an unselected group of patients with mediastinal lymphadenopathy of...

REPORT OF A CASE A woman in her 70s had right frontal anaplastic astrocytoma (World Health Organization grade III). The patient underwent a gross total tumor resection and a 6-week course of postoperative radiation therapy (6000 cGy) with concurrent TMZ (75 mg/m) by mouth daily. Four weeks after completion of radiation, she started adjuvant TMZ (150 mg/m by mouth), following the standard schedu...

An unusual case of angiolymphoid hyperplasia with eosinophilia (ALHE) simulating port-wine stain in a 50-year-old woman is reported. The lesions of ALHE are typically papules or subcutaneous masses that range from light pink to red-brown in color. In addition to the usual histologic findings of ALHE, the biopsy in our patient showed some fibrin-like material and fibrous long-spacing collagen on...

The course and prognosis of sarcoidosis varies greatly. A characteristic feature is the high rate of spontaneous remission, however, chronic disease may occur in 10–30% of patients. Chronic sarcoidosis is defined as disease which persists for w2 yrs. Mortality from sarcoidosis is only 1–5%, but 75% of all deaths are due to advanced pulmonary sarcoidosis. To date, it remains difficult to predict...

BACKGROUND AND OBJECTIVE Cellular immunity abnormalities are associated with sarcoidosis. Normal cellular immunity is required for adequate humoral immunity; therefore, a decreased humoral immune response is possible in patients with sarcoidosis. We evaluated humoral immunity by vaccinating patients with sarcoidosis against tetanus. PATIENTS AND METHOD We screened 60 patients with sarcoidosis...

Sarcoidosis is a multisystemic granulomatous disease of unknown etiology that may involve virtually any organ. Pulmonary involvement predominates, but sarcoidosis can involve multiple organs, with or without concomitant lung involvement. Aberrations on chest radiographs are present in more than 90% of patients with sarcoidosis. Bilateral hilar lymphadenopathy, with or without lung parenchymal i...

BACKGROUND Since the introduction of endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration (TBNA) of mediastinal lymph nodes, the incidence of histopathologically-confirmed sarcoidosis has increased. METHODS The electronic medical records of Chonnam National University (CNU) Hospital and CNU Hwasun Hospital (CNUHH) were searched for confirmed cases of sarcoidosis diagnosed b...

BACKGROUND Sarcoidosis is a polygenic immune disorder disease with predominant manifestations in the lung. BTNL2 gene polymorphisms were previously linked to susceptibility to sarcoidosis. Relationships between sarcoidosis and cancers have been suspected for a long time but little evidence has been reported until now, and recent works show a link between butyrophilin family proteins and anti tu...

PURPOSE OF REVIEW Sarcoidosis is a chronic granulomatous disease typically affecting the lung, lymph nodes, and other organ systems. Evidence suggests that the morbidity and mortality rates for sarcoidosis in the USA are rising, despite widespread use of anti-inflammatory therapies. In this review, we survey new therapies that target specific inflammatory pathways in other diseases (such as rhe...