DNA damage induced by numerous exogenous or endogenous factors may have irreversible consequences on the cell leading to cell cycle arrest, senescence and cell death. The DNA damage response (DDR) is powerful signaling machinery triggered in response to DNA damage, to provide DNA damage recognition, signaling and repair. Most anticancer drugs induce DNA damage, and DNA repair in turn attenuates...

wnloade nown to early investigators, DNA damage and repair has been a major focus of anticancer therapy he beginning of clinical oncology. From the early days of using x-irradiation, to the development of en mustard analogs, to today's more sophisticated approaches, DNA damage and repair has strongacted our ability to successfully treat human malignancy. This area of basic, translational, and c...

nloaded nown to early investigators, DNA damage and repair has been a major focus of anticancer therapy he beginning of clinical oncology. From the early days of using x-irradiation, to the development of en mustard analogs, to today's more sophisticated approaches, DNA damage and repair has strongacted our ability to successfully treat human malignancy. This area of basic, translational, and c...

Downloa nown to early investigators, DNA damage and repair has been a major focus of anticancer therapy he beginning of clinical oncology. From the early days of using x-irradiation, to the development of en mustard analogs, to today's more sophisticated approaches, DNA damage and repair has strongacted our ability to successfully treat human malignancy. This area of basic, translational, and c...

The rise of advanced technologies for characterizing human populations at the molecular level, from sequence to function, is shifting disease prevention paradigms toward personalized strategies. Because minimization of adverse outcomes is a key driver for treatment decisions for diseased populations, developing personalized therapy strategies represent an important dimension of both precision m...

Dicer is the key component of the RNA interference pathway. Our group and others have reported that knockdown or knockout of Dicer leads to DNA damage in mammalian cells. Two groups recently showed that efficiency of DNA damage repair was greatly reduced in Dicer-deficient cells and that Dicer-dependent small RNAs (~21 nucleotides) produced from the sequences in the vicinity of DNA double-stra...

The aim of this paper is to find the class of continuous pointwise transformations (as general as possible) in the framework of which Kummer’s transformation z(t) = g(t)y(h(t)) represents the most general pointwise transformation converting every linear homogeneous differential equation of the nth order into an equation of the same type. Further, some forms of these equations having certain sub...

Covalent attachment of ubiquitin (Ub) or SUMO to DNA repair proteins plays critical roles in maintaining genome stability. These structurally related polypeptides can be viewed as distinct road signs, with each being read by specific protein interaction motifs. Therefore, via their interactions with selective readers in the proteome, ubiquitin and SUMO can elicit distinct cellular responses, su...

O f the many issues that emerge when talking with therapists about school-based practice, one of the most critical has ro do wim third-parry agenrs (physicians, private practice occupational therapists based in medical facilities, etc.) performing independenr evaluations for children with special needs and rendering a prescription I for occupational therapy services ro be provided by the public...

The histopathological effects of Linear Alkylbenzene Sulfonate on the gill, liver and kidney tissues of the Caspian kutum, Rutilus frisii kutum were studied. The fish were exposed to three sublethal concentrations of anionic detergent, Linear Alkylbenzene Sulfonate (LAS) for short term intervals (192 h). Gill, liver and kidney samples were collected after 192 h of exposure to LAS and lesions we...