introduction: epidermoid cysts are rare, slow‑growing, benign, developmental cysts, which are derived from abnormally situated ectodermal tissue. epidermoid cysts of the floor of the mouth represent <0.01% of all oral cysts. so far, only a few cases have been reported. case report: hereby, we present a case of a giant sublingual epidermoid cyst, which was completely asymptomatic upon presentati...

Methods Data from two trials evaluating the short-ragweed SLIT-T MK-3641 (Ambrosia artemisiifolia; Merck/ALK-Abelló) were pooled. Subjects with ragweed-pollen–induced AR/C were randomized to once-daily MK-3641 (6 or 12 Amb a 1-U doses) or placebo for approximately 52 weeks. Subjects with AR/C and stable asthma not requiring mediumor high-dose inhaled corticosteroids and ≥70% predicted FEV1 were...

AIMS To determine the effect of offering smokers who want to quit easy access to nicotine replacement therapy (NRT), a period of familiarization and choice of product on smoking abstinence at 6 months. DESIGN Single-blind, randomized controlled trial. SETTING New Zealand. PARTICIPANTS A total of 1410 adult smokers who called the national Quitline for quitting support were randomized to us...

In developmental research, plasma buprenorphine concentrations comparable to a 2 mg buprenorphine-naloxone (BN) sublingual tablet have been achieved with a 0.75 mg dose of BN buccal film, a small, bioerodible polymer film for application to mucosal membranes. This was a randomized, double-blind, placebo-controlled, single-dose, four-period crossover study in opioid-dependent subjects with chron...

OBJECTIVE To compare the efficacy of sublingual and vaginal misoprostol in the medical management of missed miscarriage. METHODS Fifty women diagnosed as having missed miscarriage of gestational age less than 20 weeks were assigned randomly to receive 400 microg of either sublingual or vaginal misoprostol every three hours, up to a maximum of five doses. The primary outcome measures were, com...

BACKGROUND AND OBJECTIVES Hypertensive crisis is a condition characterized by rapid and inappropriate symptomatic elevation of blood pressure (BP) that is commonly seen in Emergency Departments. Oral or sublingual captopril is commonly used in the Emergency Departments. The unpleasant taste of the sublingual drugs causes uncomfortable condition to the patient. Studies showing no difference betw...

In early January 2022, FDA released a Drug Safety Communication surrounding dental problems following use of buccal and sublingual buprenorphine products for the treatment pain opioid disorder. The warning comes after reports problems, including tooth decay, cavities, oral infections, loss teeth, in patients using buprenorphine, regardless their history. Buprenorphine variety formulations, Subu...

ObjectiveBuprenorphine is an essential medication for the treatment of opioid use disorder (OUD), but studies show it has been underused over last 2 decades. We sought to evaluate utilization and spending on buprenorphine formulations in Medicaid impact key market regulatory factors affecting availability different generic versions.MethodsWe first identified all approved by Food Drug Administra...

Objective: To compare the effect of sublingual versus vaginal misoprostol on preoperative cervical priming in first trimester abortion. Material and methods: One hundred women seeking first trimester abortion were randomized into either sublingual or vaginal groups of 50 each. They were given 400 μg misoprostol via sublingual or vaginal route for cervical priming three hours before the procedur...

BACKGROUND This study was performed to compare intestinal and sublingual microcirculation and their response to a fluid challenge. METHODS Twenty-two septic patients in the first postoperative day of an intestinal surgery, in which an ostomy had been constructed, were evaluated both before and 20 min after a challenge of 10 mL/kg of 6% hydroxyethylstarch 130/0.4. We measured systemic hemodyna...