نتایج جستجو برای: substantia nigra
تعداد نتایج: 9934 فیلتر نتایج به سال:
Analysis of monogenic forms and candidate genes of Parkinson’s disease (PD) does not allow to describe completely the contribution of genetic factors to the etiopathogenesis of the disorder. An approach associated with an analysis of changes in a transcriptome pattern during the development of the disease in model objects can be used to identify new candidate genes that are involved in the path...
The ventral striatum is characterized by an intricate neurochemical compartmentation that is reflected in the distribution of most of its afferent fiber systems. In the present study, the compartmental relationships of ventral striatal neurons projecting to the mesencephalon were studied by combining tract tracing with the immunohistochemical localization of leu-enkephalin. Injections of the re...
As the most efficacious drug for treating Parkinson’s disease, levodopa (L-DOPA), is oft viewed as a generator of reactive oxygen species (ROS), there is a question as to whether L-DOPA might accelerate progression of Parkinson’s disease. In this context we first review the potential of both L-DOPA and dopamine (DA) to generate ROS (including catecholquinones) in the presence of iron and melani...
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