Irradiation of substituted 2-benzylidenecyclopentanone O-alkyl and O-acetyloximes in methanol provides a convenient synthesis of alkyl, alkoxy, hydroxy, acetoxy, amino, dimethylamino and benzo substituted annulated quinolines. para-Substituents yield 6-substituted-2,3-dihydro-1H-cyclopenta[b]quinolines with 8-substituted products being obtained from ortho-substituted starting materials. Reactio...

Hammett constants (σ) can be important factor to understanding substitution and position effects on benzoic acid. This report describes a computational study of ∆G◦ and σ for six substituted benzoic acid (X= F,Cl ,OH ,NH2 ,CN,NO2 )and phenylacetic acid substituted (X=OH ,NH2 ) at para and meta positions ingas and aqueousphases by DFT method and comparesit to available experimental and theoretic...

Reaction of 2-hydrazinocarbonyl-3-chloro-5-phenoxy-benzo[b] thiophene with different substituted phenyl isothiocyanate gave N-substituted arylthiosemi-carbazide derivatives (1a-h). 1,3,4-Thiadiazole derivatives (2a-h) were prepared by the cyclization of arylthiosemicarbazides (1a-h) with concentrated sulphuric acid. All the compounds were screened for their antitubercular activity against Mycob...

A series of 5-substituted-4-amino-1,2,4-triazole-3-thioesters was synthesized by converting variously substituted organic acids successively into the corresponding esters, hydrazides, 5-substituted-1,3,4-oxadiazole-2-thiols, 5-substituted-1,2,4-triazole-2-thiols and 5-substituted-1,3,4-oxadiazole-2-thioesters. Finally the target compounds were obtained by refluxing 5-substituted-1,3,4-oxadiazol...

H. Piperidine Analogues of Phenyltropanes 967 III. Cocaine Analogues 969 A. Stereoisomers of Cocaine 970 B. Phenyl Ring Substituted Cocaines 970 C. 2â-Substituted Cocaines 973 1. 2â-Substituted Cocaines 973 2. 2â-Substituted 4′-Iodococaines 977 D. N-Modified Cocaines 978 E. 3â-Carbamoyl Analogues of Cocaine 981 F. 3â-Alkylphenyltropanes 982 G. 6/7-Substituted Cocaine and Pseudococaine 982 H. 6-...

A series of N-substituted-2,4-thiazolidinedione derivatives (TZDs) were prepared via N-alkylation of 2,4-TZD at position 3 using substituted benzyl halides. Synthesized N-substituted-2,4-TZD was then substituted at position 5 with substituted aromatic aldehyde according to Knoevenagel condensation method. Structures of the compounds were elucidated using various spectral techniques viz. IR, 1HN...

starting from readily available 2-substituted-4-methylthiazole-5-carboxylic acid hydrazide (1), the title compounds were prepared. the reaction of compound 1 (r=ch3) with formic acid yielded 1-(formyl)-2-(2,4-dimethylthiazole-5-carboxyl) hydrazine (2). refluxing the latter with phosphorous pentasulfide in xylene afforded compound 3, the reaction of compound 2 with phosphorous pentoxide afforded...

A new series of 2-(ortho & para substituted phenoxy)1-(3-(3-chloro-4-methoxyphenyl)-5-(substituted phenyl)-4,5dihydropyrazol-1-yl)ethanone were synthesized. Ortho and para substituted phenol was refluxed with ethylchloroacetate in dry acetone in presence of anhydrous potassium carbonate to yield ethyl (ortho & para substituted phenoxy) acetate (1). The substituted ester on reaction with hydrazi...

Several new and know 6-(4-substituted phenyl)-4-(4-substituted phenyl)-2-phenyl-6H-1,3-thiazine (or selenazine) (Z4B7, Z4D5, Z4B7' Z4D5') were prepared by the 1,4-Michael addition reaction of chalcone derivatives with thiobenzamide or phenylselenocarboxamide in basic medium (where chalcones was formed Claisen-Schimidt condensation aromatic aldehydes 4-substituted acetophenone presence sodium hy...

A variety of novel 4-[(4'-substituted phenyl)-6-(4"-hydroxyphenyl)-2-substituted imino] pyrimidines were synthesized by reacting 4-(4'-substituted phenyl)-6-(4"-hydroxyphenyl)-2-aminopyrimidines with different substituted aromatic aldehydes, with coumarin and with chloroisatin. The 4-(4'-chlorophenyl)-6-(4"-hydroxyphenyl)-2-aminopyrimidines were synthesized by reacting 3-(4'-substituted phenyl)...