warfarin-induced skin necrosis (wisn) is a rare complication of anticoagulant therapy associated with a high incidence of  morbidity and mortality requiring immediate drug cessation. at particular risk are those with various thrombophilic abnormalities, especially when warfarinisation is undertaken rapidly with large loading doses of warfarin. cutaneous findings include petechiae that progress ...

Coumarins are secondary plant metabolites widely distributed in higher plants, bacteria, fungi, and sponges. This great structural diversity of these natural compounds their synthesized derivatives enables wide range pharmacological activities, such as antioxidant; antibacterial; antifungal; anti-human immunodeficiency infection; anti-tubercular; anti-cancer which were very well reviewed previo...

An efficient method for the C4-regiocontrolled C-H functionalization of coumarins to enable facile oxidative cross-couplings with simple arene components is disclosed.

Mosquito repellent plants are used in the rural areas of Zimbabwe despite the fact that very few of them have been biologically evaluated. Leaves of the plant Lippia javanica, were collected from Mumurwi village, Zimbabwe and evaluated for repellency against laboratory reared Aedes aegypti mosquitoes. Major plant compounds were identified using Thin Layer Chromatography (TLC) and Mass Spectrome...

One-pot reactions leading to highly functionalized coumarins have been developed via a Pd(II)-catalyzed dehydrogenation-oxidative Heck-cyclization process.