Background: Sagittal imbalance is known as the main radiographic driver of disability in adult spinal deformity (ASD).In this study, the association of radiological spinopelvic parameters and clinical outcomes was evaluated following thecorrective surgery of sagittal imbalance, in order to explore the predictive ability of each parameter.Methods: A total of 23 patients, who underwent corrective...

BACKGROUND The clinical impact of arrhythmias on the continuum of critical illness is unclear, and data in medical intensive care units (ICU) is lacking. In this study, we distinguish between different types of arrhythmias and evaluate if their distinction is of clinical importance based on ICU length of stay and mortality outcomes. METHODS We performed a retrospective analysis of 215 patient...

All current 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors [simvastatin (SV), lovastatin (LV), atorvastatin, pravastatin, fluvastatin, and cerivastatin] are believed to undergo an atypical -oxidation of the dihydroxy heptanoic or heptanoic acid side chain. Metabolites, which are shortened by twoand/or four-carbon units consistent with -oxidation products, have been reported exclusively in ...

BACKGROUND Recent studies have demonstrated sagittal spinal balance was more important than coronal balance in terms of clinical result of surgery for adult spinal deformity. Notably, Schwab reported that one of the target spinopelvic parameters for corrective surgery was that pelvic incidence (PI) minus lumbar lordosis (LL) should be within +/- 10 °. The present study aimed to investigate whet...

The ability to maintain and study human tissues in in-vivo environment has proved to be a valuable tool in breast cancer research for several decades. The most widely tissues have been xenografts established human breast cancer cell lines into athymic nude mice. The aim of this study was to provide a new accurate and affordable method for the establishment of breast cancer xenograftin nude mice...

Retrotransposons constitute over 40% of the human genome and play important roles in the evolution of the genome. Since certain types of retrotransposons, particularly members of the Alu, L1, and SVA families, are still active, their recent and ongoing propagation generates a unique and important class of human genomic diversity/polymorphism (for the presence and absence of an insertion) with s...

The reduced-gravity environment in space is known to cause an upward shift in body fluids and thus require cardiovascular adaptations in astronauts. In this study, we recorded in rats the neuronal activity in the subthalamic cerebrovasodilator area (SVA), a key area that controls cerebral blood flow (CBF), in response to partial gravity. "Partial gravity" is the term that defines the reduced-gr...