Remember when everybody said taking estrogen did not increase breast cancer for years and years women were prescribed estrogen, because study after study said there was no increased risk in taking the drug. Then one very large study seemed to say there was a risk and many women stopped taking it on their own even though most doctors did not stop prescribing it women stopped taking it and all th...

T his is a case of a 47-year-old German lorry driver with very limited English who presented with sudden onset of a neck pain followed by an occipital headache while he was on the motorway. The pain forced him to stop his vehicle and call a friend who brought him to accident and emergency department. On examination, he had unsteady gait, slight dysarthria and subtle horizontal nystagmus on extr...

When two or more candle flames are fused by approaching them together, the resulting large flame often exhibits flickering, i.e., prolonged high-frequency oscillation in its size and luminance. In the present work, we investigate the collective behaviour of three-coupled candle flame oscillators in a triangular arrangement. The system showed four distinct types of syncronised modes as a consequ...

Prolonged administration of corticosteroid preparations, other than by the inhaled route, is associated with suppression of the hypothalamicpituitary-adrenocortical axis. Sudden cessation of such treatment may lead to acute adrenal insufficiency that could have a fatal consequence, and for this reason a card is available for issue to patients receiving corticosteroid supplements. Drug type, dos...

Adaptive behavior requires the ability to flexibly control actions. This can occur either proactively to anticipate task requirements, or reactively in response to sudden changes. Recent work in humans has identified a network of cortical and subcortical brain region that might have an important role in proactive and reactive control. However, due to technical limitations, such as the spatial a...

We report a case of systemic lupus erythematosus (SLE) in a 44-year old Caucasian woman complicated with pneumonia and severe respiratory failure requiring ICU treatment and mechanical ventilation. Symptoms developed in a generally well controlled SLE course after sudden stop in immunosupresant therapy (methotrexate, cyclosporin and methylprednisolone). A fulminant course of the disease, an int...

Abstract The research project was carried out to estimate the robustness of flat steel-framed structures in a selected accidental situation. For this purpose, multistage approach based on experimental tests and numerical analysis performed. As main objective work, dynamic steel frames performed under sudden gradual internal column loss scenario. FEA models were created Abaqus software using sol...

Capital flows into emerging markets are volatile and associated with risks. A common prescription is to impose counter-cyclical capital controls that tighten during economic booms mitigate future sudden-stop dynamics, but it has been challenging document such patterns in the data. Instead, we show their response volatility international financial elevated risk aversion. We develop a model which...

Hypertrophic cardiomyopathy is an autosomal dominant inherited disease characterized by ventricular hypertrophy and myofibril disarray. Mutations responsible for hypertrophic cardiomyopathy have been identified in 11 genes that encode for cardiac sarcomere proteins. Traditionally, hypertrophic cardiomyopathy due to mutation of the myosin-binding protein C gene (MYBPC3) has been thought to follo...

Regular and prolonged exercise is associated with increased left ventricular wall thickness that can overlap with hypertrophic cardiomyopathy (HCM). Differentiating physiological from pathological hypertrophy has important implications, since HCM is the commonest cause of exercise-related sudden cardiac death in young individuals. Most deaths have been reported in intermittent 'start-stop' spor...