To the Editor—We read with interest the report by Mizuta and colleagues on the role of a combination antibiogram for empirical treatment of Pseudomonas aeruginosa infection. The emergence of multidrug-resistant (MDR) gramnegative microorganisms, especially Acinetobacter baumannii, has created prescribing dilemmas for physicians trying to select empirical therapy. In Thailand, the national incid...

In mice, a selective decontamination of the digestive tract regimen consisting of orogastric tobramycin, polymyxin E, and amphotericin B in combination with subcutaneous cefepime inhibited gram-negative bacilli, including Klebsiella pneumoniae, and did not promote vancomycin-resistant Enterococcus spp. (VRE) colonization. However, concurrent administration of subcutaneous ampicillin-sulbactam r...

The kinetic activity of KPC-3, a plasmid-encoded class A carbapenemase, was studied. It hydrolyzed penicillins, cephalosporins, carbapenems, and even sulbactam. The best substrate was cephalothin (k(cat/K)m = 3.48 microM(-1) s(-1)). The efficiency of the enzyme was similar for imipenem and meropenem (k(cat)/K(m), 1.4 and 1.94 microM(-1) s(-1), respectively).

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Effects of a /J-Lactamase Inhibitor, Sulbactam, on the Activity of Carbapenems against Pseudomonasaeruginosa Nobuyoshi Hazumi *, Yoshiaki Kato, Terutaka Hashizume and Kouji Matsuda Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd., Tsukuba Techno-Park Oho, Okubo 3, Tsukuba 300-33, Japan (Received for publication April 17, 1995) Imipenem, one of the most powerful antibiotic agents, is w...

Background: While preoperative antibiotic therapy is standard to prevent surgical site infections in acute calculous cholecystitis, prescribing antibiotics after discharge controversial. This study aimed investigate the effect of administration prescription on infections.
 Methods: Data from patients who underwent emergency laparoscopic cholecystectomy for cholecystitis between January 201...

ABT-773 was tested against 317 fastidious isolates; it inhibited 99% of organisms at a concentration of 4.0 microg/ml. With ampicillin-sulbactam and levofloxacin, only 2 and 6% of these strains, respectively, were resistant at the breakpoint. With clindamycin, penicillin G, and metronidazole, 22, 26, and 58% of the strains, respectively, were resistant.

Garenoxacin (BMS 284756) was active against 105 of 108 (97%) recent clinical Gardnerella vaginalis isolates at < or =2 micro g/ml by using the reference agar dilution method for anaerobes. Twenty-eight percent of isolates (31 of 108) were resistant to metronidazole, and 44% were resistant to doxycycline. All were susceptible to clindamycin and ampicillin-sulbactam.

Yersinia enterocolitica serotype 0:5,27 biotype 2 was isolated from the intestinal contents of a common garter snake (Thamnophis sirtalis). The isolate possessed virulence associated phenotypes in all tests conducted. It was susceptible to amikacin, ampicillin/sulbactam, aztreonam, cefoperazone, cefotaxime, ceftazidime, ceftriaxone, cefuroxime, ciprofloxacin, gentamicin, imipenem, mezlocillin, ...

Tests were performed with 104 anaerobic microorganisms to evaluate the thioglycolate disk elution technique for the detection of resistance to cefoperazone and cefoperazone-sulbactam. An unacceptably high false-resistance rate and a poor reproducibility record make the disk elution procedure unsatisfactory for routine testing of this drug or combination of drugs.