Sulfonamide and amide derivatives of tris(aminoethyl)amine (TREN) are known to facilitate phospholipid translocation across vesicle and erythrocyte membranes; that is, they act as synthetic translocases. In this report, a number of new TREN-based translocases are evaluated for their abilities to bind phosphatidylcholine and translocate a fluorescent phosphatidylcholine probe. Association consta...

The problem of resistance to sulfonamide therapy1 in male gonorrhea is well known. Cox (1) states that, in varying degrees, clinical resistance is found in approximately 25 per cent of cases treated with sulfadiazine or sulfathiazole. More recently, the incidence of resistance has risen to approximately 50 per cent of cases admitted to the Boston Dispensary (2). This resistance is manifested ei...

Periplasmic α-carbonic anhydrase of Helicobacter pylori (HpαCA), an oncogenic bacterium in the human stomach, is essential for its acclimation to low pH. It catalyses the conversion of carbon dioxide to bicarbonate using Zn(II) as the cofactor. In H. pylori, Neisseria spp., Brucella suis and Streptococcus pneumoniae this enzyme is the target for sulfonamide antibacterial agents. We present stru...

Marine bacteria are possible reservoirs of antibiotic-resistance genes (ARGs) originating not only from clinical and terrestrial hot spots but also the marine environment. We report here for first time a higher rate sulfonamide-resistance gene sul4 in bacterial isolates compared with other sul genes. Among four ( sul1 , sul2 sul3 ), was most abundant (45%) 74 sulfonamide-resistant by PCR screen...

Sulfonamide groups, commonly used as neutral hydrogen bond donors in a wide variety of anion receptors, deprotonate upon addition of certain basic anionic guests in two simple functionalised ureas.

Asymmetric conjugate additions of branched aldehydes to vinyl sulfones promoted by sulfonamide organocatalyst 6 or 7 have been developed, allowing facile synthesis of the corresponding adducts with all-carbon quaternary stereocenters in excellent yields with up to 95% ee.

Background and Aims: Sulfonamide drugs are a very old noted group of small molecules, still one the most important antimicrobial compounds. In this study, starting from sulfonamide drugs, new original compounds containing frequent functional rings such as thiazole pyridine were synthesized their effects evaluated. Methods: Eighteen by converting 4-amino sulfonamides to thiourea, continued ring ...

Phenazopyridine, at its maximum tolerated dose, did not affect the effectiveness of sulfonamides against uropathogenic bacterial species in mice.