Many drugs may produce a syndrome closely resembling spontaneous systemic lupus erythematosus (SLE). Those most commonly implicated are hydrallazine, isoniazid, and procainamide. Drugs less commonly implicated include the following. Antimicrobials-sulphonamides, penicillins, tetracycline, strepto-`mycin, and para-amino salicylic acid; Antithyroid drugs-methylthiouracil and propylthiouracil; Ant...

ALTHOUGH the use of topical sulphonamides, as compared with antibiotics, is becoming less popular in the mass or community treatment of trachoma, the introduction of long-acting sulphonamides has renewed the interest of trachomatologists in their suitability for use in such programmes. Clinical trials with Lederkyn conducted by Bietti and Lanzieri (1957), Rochat (1958), Lanzieri and Latte (1960...

to hand, and it appears to be one of growing importance. We therefore refer to the subject again. The idea that vitamins could be synthesized in the gut was suggested about 30 years ago, and the occurrence of it in the gut of animals was first demonstrated 20 years ago. The production of vitamins in the gut of animals has been attributed to the presence of various micro-organisms in the gut. Vi...

UNLABELLED Infections caused by bacterial species are common in immunocompromised patients and carry significant treatment costs and mortality. The emerging resistance of microorganisms to some synthetic antimicrobial agents makes it necessary to continue the research for new antimicrobial drugs. AIM To design new sulphonamide compounds with potential antibacterial and antioxidant activity. ...

The effect of the modifier concentration and flow rate on the chromatographic performance of a second generation Chromolith® RP-18e column, under isocratic and gradient elution with acetonitrile-water mixtures, was examined using four sulphonamides as probe compounds. The acetonitrile concentration was varied between 5 and 55% (v/v), and the flow rate between 0.1 and 5.0 mL/min, keeping the oth...

is apparently 50% regeneration; (b) Ama. is shifted about 8 m,u. towards shorter wavelengths. 2. This result has been obtained with frog, rat and ox rhodopsin, and the amount of regeneration is, within the experimental error, 50%. 3. A working hypothesis concerning the structure of the rhodopsin chromophore and the mechanism of its photodecomposition is presented. One of us (F. D. C.) participa...