introduction: spreading depression (sd) is a propagating wave of depolarization followed by depression of the neuroglial activities and can modulate extracellular dopamine concentrations in the neocortex. it has been shown that the dopaminergic system plays a role in migraine. sd has been suggested as a critical phenomenon in the pathophysiology of migraine. the aim of this study was to investi...

in this study, the influence of dopamine receptor agonists and antagonists on antinociception induced by bac10fen has been examined in the formalin test. the gaba-b agonist bac10fen induced antinociception in both phases of the formalin test in mice. the dopamine receptor agonists skf 38393 and quinpirole also induced antinociception in both phases of the test. skf 38393 but not quinpirole pote...

Classical (chlorpromazine, haloperidol) and atypical (sulpiride and clozapine) neuroleptics applied for a period of 2 weeks diminished neuropeptide Y (NPY) levels in nucleus accumbens, but not in striatum. These changes were correlated with NPY mRNA level. However, the effect of these neuroleptics on the level of NPY in hypothalamus was different. It is suggested that changes in NPY levels caus...