Vascular injury increases nitric oxide (NO) levels, and this effect may play a counterregulatory role in neointima formation, by decreasing vascular smooth muscle cell motility. However, the mechanisms underlying this effect are not well established. We tested the hypothesis that NO decreases cell motility by increasing the activity of a protein tyrosine phosphatase (PTP), PTP-PEST, in cultured...

Pest insects pose a significant threat to food production worldwide resulting in annual losses worth hundreds of billions of dollars. Pest control attempts to prevent pest outbreaks that could otherwise destroy a sward. It is good practice in integrated pest management to recommend control actions (usually pesticides application) only when the pest density exceeds a certain threshold. Accurate ...

An important step in carcinoma progression is loss of cell-cell adhesion leading to increased invasion and metastasis. We show here that the protein tyrosine phosphatase, PTP-PEST, is a critical regulator of cell-cell junction integrity and epithelial cell motility. Using colon carcinoma cells, we show that the expression level of PTP-PEST regulates cell motility. Either transient small interfe...

KD har i en nylig proposisjon foreslått endringer av klagesensurordningen, hvor det legges opp til at en modell med blind omsensur, som allerede har vært brukt ved en del læresteder, nå skal gjøres obligatorisk for alle læresteder. I denne artikkelen sammenlignes gammel og ny klagesensurordning med ordningene i en del andre land. Vi diskuterer ulike typer sensurfeil (med eksempel fra programmer...

Dermatology clinics represent a key opportunity to screen patients with psoriasis for psoriatic arthritis (PA) which often remains unrecognised. A significant proportion of adults with psoriasis develop arthropathy [5] with around two-thirds having progressive arthritis.[6] NICE has recognised this by the annual use of a validated screening tool such as psoriasis epidemiological screening tool ...

Lin, Yi, Alice Corina Ceacareanu, and Aviv Hassid. Nitric oxide-induced inhibition of aortic smooth muscle cell motility: role of PTP-PEST and adaptor proteins p130cas and Crk. Am J Physiol Heart Circ Physiol 285: H710–H721, 2003. First published April 24, 2003; 10.1152/ajpheart.01127. 2002.—Vascular injury increases nitric oxide (NO) levels, and this effect may play a counterregulatory role in...