Human manganese superoxide dismutase is a mitochondrial metalloenzyme that is involved in protecting aerobic organisms against superoxide toxicity, and has been implicated in slowing tumor growth. Unfortunately, this enzyme exhibits strong product inhibition, which limits its potential biomedical applications. Previous efforts to alleviate human manganese superoxide dismutase product inhibition...

BACKGROUND AND AIMS Excessive production of reactive oxygen metabolites (ROMs) by phagocytic cells is thought to contribute to the mucosal pathology of Helicobacter pylori infection. Previously, H pylori infection was shown to have a differential effect on some gastric mucosal scavenger enzymes of ROMs-namely, mitochondrial and cytoplasmic superoxide dismutases-reflected by a large increase in ...

In aerobic organisms, protection against oxidative damage involves the combined action of highly specialized antioxidant enzymes, such as copper-zinc superoxide dismutase. In this work, a cDNA clone which encodes a copper-zinc superoxide dismutase gene, named PS-CuZnSOD, has been identified from P. sibiricum Laxm. by the rapid amplification of cDNA ends method (RACE). Analysis of the nucleotide...

the present study aimed to evaluate the protective effect of crocin on gastric mucosal lesions caused by ischemia-reperfusion (i/r) injury in rats.forty male rats were randomly divided into sham, control (i/r injury) and three crocin-pretreated groups. to induce i/r lesions, the celiac artery was clamped for 30 min and then the clamp was removed to allow reperfusion for 3 h. pretreated-rats rec...

background: non-steroidal anti-inflammatory drugs (nsaid) have been associated with antioxidant property and have been shown to improve the circulating antioxidant status on daily dosing in different inflammatory conditions. the present study was conducted to investigate the antioxidant role of meloxicam in aluminum induced oxidative stress in rat brain. methods: in the in vivo experiments, spr...

a valuable composition of mentha piperita l. essential oil is menthol that is widely used fordifferent industries. the plants were treated with different concentrations of methyl jasmonate (meja) and after 24 h were evaluated for total soluble proteins, chlorophylls (a, b, and total), malondialdehyde, carbohydrates and antioxidant enzymes (superoxide dismutase and guaiacol peroxidase). variance...

background: there is growing evidence that damage to spermatozoa by reactive oxygen species (ros) play a key role in male infertility. objective: the aim of the present study was to assess the antioxidant status of seminal plasma by measuring total antioxidant capacity (tac) and activities of catalase and superoxide dismutase (sod) in men with asthenozoospermia, asthenoteratozoospermia and olig...

Superoxide dismutase (oxide dismutase) is an enzyme synthesized via the expression of SOD-related genes. It first line defense against oxygen free radicals, and it widely exists in cytoplasm, chloroplasts, mitochondria. However, SOD gene family woody plant Liriodendron chinense has not been studied. To reveal potential role genes, we systematically identified analyzed L. chinense, investigated ...

diabetes mellitus (dm) is a chronic heterogeneous disorder and oxidative stress is a key participant in the development and progression of it and its complications. anti-oxidant status can affect vulnerability to oxidative damage, onset and progression of diabetes and diabetes complications. superoxide dismutase 2 (sod2) is one of the major antioxidant defense systems against free radicals. sod...

Circular RNAs (CircRNAs) are covalently closed non-coding that play an important role in a variety of biological processes. CircRNA profiling helps to understand process associated with various abiotic and biotic stresses. In tomato genotype IIHR- 2611 (resistant ToLCBaV), total 193 CircRNAs were discovered, which 72 121 found control (RC) ToLCBaV inoculated (RI) plants respectively. Among them...