Oxidative stress enhances inflammation and reduces the effectiveness of corticosteroids, but the inflammatory signalling pathways induced by oxidants remain ill-defined. Phosphorylation of histone 3 at serine 10 (H3-Pser10) marks out a subset of inflammatory genes for transcription, several of which are induced in oxidant-associated inflammation. However, the influence of oxidants or of cortico...

Iron oxides catalyze the conversion of hydrogen peroxide (H(2)O(2)) into oxidants capable of transforming recalcitrant contaminants. Unfortunately, the process is relatively inefficient at circumneutral pH values because of competing reactions that decompose H(2)O(2) without producing oxidants. Silica- and alumina-containing iron oxides prepared by sol-gel processing of aqueous solutions contai...

Sasaki, Makoto, D. Ostanin, J. W. Elrod, T. Oshima, P. Jordan, M. Itoh, T. Joh, A. Minagar, and J. S. Alexander. TNF-induced endothelial cell adhesion molecule expression is cytochrome P-450 monooxygenase dependent. Am J Physiol Cell Physiol 284: C422–C428, 2003. First published September 4, 2002; 10.1152/ajpcell.00271.2002.—It is strongly suspected that cytokine-induced gene expression in infl...

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background & aim: the most common primary brain tumors of the central nervous system are gliomas. among a number of different biomolecular events, a strong relation between oxidative stress pathways and the development of this cancer has been proved. oxidative stress (os) is the consequence of an imbalance between pro-oxidants and antioxidants towards pro-oxidants. the pro-oxidants cause lipid ...

Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by deposits of βamyloid peptide (Aβ) and insoluble hyperphosphorylated Tau protein. Cathepsin D (CTSD) is the main lysosomal protease and it has been suggested as hyperphosphorylated Tau-degradating enzyme. Oxidants such as hydrogen peroxide (H2O2) and nitric oxide (NO) and its derivatives, Snitrosoglutathione (GS...

Elevated levels of oxidants in biological systems have been historically referred to as "oxidative stress," a choice of words that perhaps conveys an imbalanced view of reactive oxygen species in cells and tissues. The term stress suggests a harmful role, whereas a contemporary view is that oxidants are also crucial for the maintenance of homeostasis or adaptive signaling that can actually limi...

Global gene expression patterns in breast cancer cells after treatment with oxidants (hydrogen peroxide, menadione, and t-butyl hydroperoxide) were investigated in three replicate experiments. RNA collected after treatment (at 1, 3, 7, and 24 h) rather than after a single time point, enabled an analysis of gene expression patterns. Using a 17,000 microarray, template-based clustering and multid...

OBJECTIVES The aim of this study was to determine the effect of exposure to sublethal concentrations of chlorhexidine on oxidative stress protection by Acinetobacter baylyi ADP1. METHODS ADP1 cultures were exposed to sublethal concentrations of chlorhexidine prior to being challenged with lethal concentrations of chlorhexidine itself and by oxidants. Oxidant-sensitive dyes and a flow cytomete...

Indoor, outdoor pollutants and climatic conditions in the growing environment can develop childhood asthma atopic dermatitis. Therefore, it is important to identify environmental burden of community on risk To clarify relationship between regional prevalence rate dermatitis among first grade elementary school students preschool indoor such as smoking rate, photochemical oxidants concentration, ...