Plasticity of feedforward inhibition in the hippocampal mossy fiber (MF) pathway can dramatically influence dentate gyrus-CA3 dialog. Interestingly, MF inputs to CA3 stratum lucidum interneurons (SLINs) undergo long-term depression (LTD) following high-frequency stimulation (HFS), in contrast to MF-pyramid (PYR) synapses, where long-term potentiation (LTP) occurs. Furthermore, activity-induced ...

The formation of imprinted memories during a critical period is crucial for vital behaviors, including filial attachment. Yet, little is known about the underlying molecular mechanisms. Using a combination of behavior, pharmacology, in vivo surface sensing of translation (SUnSET) and DiOlistic labeling we found that, translational control by the eukaryotic translation initiation factor 2 alpha ...

Long-term memory relies on modulation of synaptic connections in response to experience. This plasticity involves trafficking of AMPA receptors (AMPAR) and alteration of spine morphology. Arc, a gene induced by synaptic activity, mediates the endocytosis of AMPA receptors and is required for both long-term and homeostatic plasticity. We found that Arc increases spine density and regulates spine...

AMPA receptors (AMPARs) mediate fast excitatory synaptic transmission and are crucial for synaptic plasticity, learning, and memory. However, the molecular control of AMPAR stability and its neurophysiological significance remain unclear. Here, we report that AMPARs are subject to lysine acetylation at their C termini. Acetylation reduces AMPAR internalization and degradation, leading to increa...

Boundaries and junctions (both internal and external) can contribute significantly to the plastic deformation of metallic solids, especially when the average size of the grains (phases) is less than hundred nanometres or when the size of the solid itself is of the order of microns. The overall permanent deformation of the solid is a result of a coupling between bulk plasticity with moving inter...

Regulation of AMPA receptor trafficking is important for many forms of neuronal plasticity. In this study, a protein cross-linking assay was used to evaluate the contribution of AMPA receptor trafficking to plasticity associated with behavioral sensitization, an animal model of drug addiction. Cross-linking was used to distinguish between cell surface and intracellular AMPA receptors in nucleus...

Key words: phenotypic plasticity, effect of use on Hominoid ankle shape, effect of habitat on behavior. The hominin fossil record is punctuated by variation and rapid change in talo-crural articular joint shape. Prior studies in a diverse Catarrhine sample using Singular Warp analysis has revealed that similar shape is observed across superfamilies due to substrate use, but genera can differ in...

The UHMWPE has a plastic behaviour but it is specified only the surface wear, unless the evaluation of the great importance of this behaviour of plasticity for the calculation of the depth of penetration. This work tries to demonstrate the fact that there are components of the wear by plastic deformation. Also, by this type of wear an explanation of smooth surface of the UHMWPE in the contact z...

Behavioral and/or developmental plasticity is crucial for resisting the impacts of environmental stressors. We investigated the plasticity of adult foraging behavior and chick development in an offshore foraging seabird, the black noddy (Anous minutus), during two breeding seasons. The first season had anomalously high sea-surface temperatures and 'low' prey availability, while the second was a...