نتایج جستجو برای: sustained release tablets

تعداد نتایج: 299466  

2012
Aiman A. Obaidat

The specific aim of this study was to prepare sustained release matrix tablets containing indapamide as a low dose and low water solubility model drug. The matrix formers were composed of blends of hydroxypropyl methylcellulose as a swellable polymer and methyl cellulose as an erodible polymer. The matrix tablets were prepared by the direct compression technique and they have shown robust and a...

Journal: :INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH 2016

2013
Jadupati Malakar Amitava Ghosh Souvik Ghatak

2 The work investigates the formulation development, evaluation and optimization of ibuprofen effervescent tablet using 3 factorial designs. The effect of variables viz. xanthan gum and sodium bicarbonate on drug release and hardness of ibuprofen effervescent tablets were analyzed and optimized. The optimized formulation showed the ibuprofen release in sustained manner over a period of 6h. The ...

2010
N. RADOMAN S. IBRIĆ

The study demonstrates two approaches in formulation of solid oral lipid-based diazepam preparations (BCS class II drug). The aim of the study was to formulate tablets and hard capsules, using emulsifier and adsorbent. Lipidbased preparations improve drug solubility and permeability, i. e. bioavailability. Solid silicate carriers are able to adsorb liquid lipid formulations, resulting in freely...

Journal: :Current drug delivery 2010
Marilena Vlachou Hani Naseef Manuel Efentakis

The purpose of this research was to develop and evaluate different sustained release preparations, using swellable polymers as carriers in the form of matrices and three-layer tablets. These preparations may offer a number of therapeutic advantages over immediate release dosage forms in drug delivery. The materials used for the fabrication of these systems were hydrophilic swellable polymers na...

2016
Jeong Soo Kim Kwang Ho Cha Seung Yeob Kang Donghan Won Sun Woo Jang Miwon Son Moon Ho Son Ho Jung Choi Young Won Lee Myung Joo Kang

OBJECTIVE DA-9601, an extract of Artemisia asiatica containing eupatilin and jaceosidin as active compounds, has been prescribed to treat gastritis in Asia. In recent times, sustained-release, floating gastroretentive (GR) tablets of DA-9601 are available on the market. In the present study, the physical properties and in vitro drug release profile, in vivo gastric residence time, and gastropro...

2009
NITIN SHARMA ANJANA SHARMA KANCHAN KOHLI SAURABH ARORA

Dextromethorphan HBr is a synthetic antitussive compound. Biological half life of this drug is 2 to 4 hours. Due to its shorter half life the dose is upto 4 times a day, thereby reducing patient compliance. Thus to reduce the dose frequency and to improve the patient compliance sustained release tablets of freely water soluble Dextromethorphan HBr. was formulated with non-swellable waxy polymer...

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