نتایج جستجو برای: syn
تعداد نتایج: 6081 فیلتر نتایج به سال:
Accumulation of misfolded alpha-synuclein (α-syn) into Lewy bodies (LBs) and Lewy neurites (LNs) is a major hallmark of Parkinson's disease (PD) and dementia with LBs (DLB). Recent studies showed that synthetic preformed fibrils (pffs) recruit endogenous α-syn and induce LB/LN pathology in vitro and in vivo, thereby implicating propagation and cell-to-cell transmission of pathological α-syn as ...
Alpha-synuclein (alpha-syn) is an important component of neuronal and glial inclusions in brains of patients with several neurodegenerative disorders. Sporadic inclusion-body myositis (s-IBM) is the most common progressive muscle disease of older patients. Its muscle phenotype shows several similarities with Alzheimer disease brain. A distinct feature of s-IBM pathology is specific vacuolar deg...
α-Synuclein (α-Syn) is a major component of protein inclusions known as Lewy bodies, which are hallmarks of synucleinopathies such as Parkinson's disease (PD). The α-Syn gene is one of the familial PD-causing genes and is also associated with an increased risk of sporadic PD. Numerous studies using α-Syn expressing transgenic animals have indicated that α-Syn plays a critical role in the common...
The aggregation of proteins into oligomers and amyloid fibrils is characteristic of several neurodegenerative diseases, including Parkinson disease (PD). In PD, the process of aggregation of α-synuclein (α-syn) from monomers, via oligomeric intermediates, into amyloid fibrils is considered the disease-causative toxic mechanism. We developed α-syn mutants that promote oligomer or fibril formatio...
α-Synuclein (α-Syn) is hypothesized to have a critical role in sporadic and genetic cases of Parkinson's disease (PD) in which Lewy bodies, as the hallmark of PD, are formed from abnormal aggregates of α-Syn. To determine the role of α-Syn in the motor and cognitive dysfunction observed in PD, a Drosophila melanogaster model was established to investigate the electrophysiological and ethologica...
Hydroxyurea (HU) inhibits ribonucleotide reductase (RNR), which catalyzes the rate-limiting synthesis of deoxyribonucleotides for DNA replication. HU is used to treat HIV, sickle-cell anemia and some cancers. We found that, compared with vector control cells, low levels of alpha-synuclein (α-syn) protect S. cerevisiae cells from the growth inhibition and reactive oxygen species (ROS) accumulati...
In this paper, we analyze the stateless SYNSYN&ACK and SYN-FIN/RST detection mechanisms for TCP SYN attacks. We indicate the inherent vulnerability of the SYN-FIN/RST detection mechanism caused by the computation of the RST packet counts. We indicate why SYNSYN&ACK is a more efficient and reliable detection mechanism than SYN-FIN/RST. We come up with ‘Bot Buddies’ for TCP SYN attacks and explai...
Pristocera afra Magretti, 1884 which currently belongs to genus Epyris Westwood is revised and redescribed. The lectotype of P. afra Magretti is designated. New synonymy is proposed for Epyris afer (Magretti, 1884): Epyris pilosipes Kieffer, 1904, syn. nov.; Epyris analis Kieffer, 1905, syn. nov.; Epyris secundus Brues, 1906, syn. nov.; Epyris rugicollis Cameron, 1906, syn. nov.; Epyris plurili...
The paper analyzes systems vulnerability targeted by TCP (Transmission Control Protocol) segments when SYN flag is ON, which gives space for a DoS (Denial of Service) attack called SYN flooding attack or more often referred as a SYN flood attack. The effects of this type of attack are analyzed and presented in OPNET simulation environment. Furthermore, the paper presents two anomaly detection a...
Direct excitation of acenaphthylene molecules included in a syn fashion within the octa acid nanocapsule dimerizes quantitatively to a syn dimer, and upon triplet sensitization, yields both syn and anti dimers probably by reacting within and outside the capsule.
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