نتایج جستجو برای: synaptic terminal

تعداد نتایج: 207353  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2003
Angela Ho Wade Morishita Robert E Hammer Robert C Malenka Thomas C Sudhof

Mints (also called X11-like proteins) are adaptor proteins composed of divergent N-terminal sequences that bind to synaptic proteins such as CASK (Mint 1 only) and Munc18-1 (Mints 1 and 2) and conserved C-terminal PTB- and PDZ-domains that bind to widely distributed proteins such as APP, presenilins, and Ca(2+) channels (all Mints). We find that Mints 1 and 2 are similarly expressed in most neu...

Journal: :Neuron 2008
Iris Koch Heinz Schwarz Dirk Beuchle Bernd Goellner Maria Langegger Hermann Aberle

Synaptic connections are stabilized through transsynaptic adhesion complexes that are anchored in the underlying cytoskeleton. The Drosophila neuromuscular junction (NMJs) serves as a model system to unravel genes required for the structural remodeling of synapses. In a mutagenesis screen for regulators of synaptic stability, we recovered mutations in Drosophila ankyrin 2 (ank2) affecting two g...

Journal: :iranian journal of medical sciences 0
chengdong yuan guizhou key laboratory of anesthesia and organ protection, zunyi medical college, guizhou, china yajun zhang guizhou key laboratory of anesthesia and organ protection, zunyi medical college, guizhou, china yu zhang guizhou key laboratory of anesthesia and organ protection, zunyi medical college, guizhou, china song cao guizhou key laboratory of anesthesia and organ protection, zunyi medical college, guizhou, china yuan wang guizhou key laboratory of anesthesia and organ protection, zunyi medical college, guizhou, china bao fu guizhou key laboratory of anesthesia and organ protection, zunyi medical college, guizhou, china

background: ketamine is a commonly used intravenous anesthetic which produces dissociation anesthesia, analgesia, and amnesia. the mechanism of ketamine-induced synaptic inhibition in high-level cortical areas is still unknown. we aimed to elucidate the effects of different concentrations of ketamine on the glutamatergic synaptic transmission of the neurons in the primary somatosensory cortex b...

Journal: :The Journal of physiology 2011
Giovanna Bucci Sumiko Mochida Gary J Stephens

Modulation of presynaptic voltage-dependent Ca2+ channels is a major means of controlling neurotransmitter release. The CaV2.2Ca2+ channel subunit contains several inhibitory interaction sites for Gβγ subunits, including the amino terminal (NT) and I-II loop. The NT and I-II loop have also been proposed to undergo a G protein-gated inhibitory interaction, whilst the NT itself has also been prop...

Journal: :The Journal of Biophysical and Biochemical Cytology 1956
Eduardo De Robertis Carlos M. Franchi

The submicroscopic organization of the rod and cone synapses of the albino rabbit has been investigated with the use of the electron microscope. The most common rod synapse consists of an enlarged expansion of the rod fiber (the so called spherule) into which the dendritic postsynaptic fiber of the bipolar cell penetrates and digitates. The membrane surrounding the terminal consists of a double...

Journal: :Journal of neurophysiology 2008
John A Hickman J Marie Hardwick Leonard K Kaczmarek Elizabeth A Jonas

A role for BCL-xL in regulating neuronal activity is suggested by its dramatic effects on synaptic function and mitochondrial channel activity. When recombinant BCL-xL is injected into the giant presynaptic terminal of squid stellate ganglion or applied directly to mitochondrial outer membranes within the living terminal, it potentiates synaptic transmission acutely, and it produces mitochondri...

2007
John A. Hickman J. Marie Hardwick Leonard K. Kaczmarek Elizabeth A. Jonas

2 Summary A role for BCL-xL in regulating neuronal activity is suggested by its dramatic effects on synaptic function and mitochondrial channel activity. When recombinant BCL-xL is injected into the giant presynaptic terminal of squid stellate ganglion or applied directly to mitochondrial outer membranes within the living terminal, it potentiates synaptic transmission acutely, and it produces m...

2014
Donal Stewart Stephen Gilmore Michael A. Cousin

Synaptic vesicle recycling at the presynaptic terminal of neurons is essential for the maintenance of neurotransmission at central synapses. Among the tools used to visualise the mechanics of this process is time-series fluorescence microscopy. Fluorescent dyes such as FM143, or engineered fluorescent versions of synaptic vesicle proteins such as pHluorins, have been employed to reveal di↵erent...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1991
J E Cavazos G Golarai T P Sutula

Recent studies have revealed that mossy fiber axons of granule cells in the dentate gyrus undergo reorganization of their terminal projections in both animal models of epilepsy and human epilepsy. This synaptic reorganization has been demonstrated by the Timm method, a histochemical technique that selectively labels synaptic terminals of mossy fibers because of their high zinc content. It has b...

Journal: :Molecular and cellular neurosciences 2013
Lauren K Buhl Ramon A Jorquera Yulia Akbergenova Sarah Huntwork-Rodriguez Dina Volfson J Troy Littleton

Complexins are small α-helical proteins that modulate neurotransmitter release by binding to SNARE complexes during synaptic vesicle exocytosis. They have been found to function as fusion clamps to inhibit spontaneous synaptic vesicle fusion in the absence of Ca(2+), while also promoting evoked neurotransmitter release following an action potential. Complexins consist of an N-terminal domain an...

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