Heavy atom nanoparticles have high X-ray absorption capacity and near infrared (NIR) photothermal conversion efficiency, which could be used as radio-sensitizers. We hypothesized that concave PtCu octopod nanoframes (OPCNs) would be an efficient nanoplatform for synergistic radio-photothermal tumor ablation. Methods: In this study, we newly exploited a folic acid-receptor (FR) mediated photothe...

Stem cell factor (SCF) and erythropoietin (EPO) work synergistically to support erythropoiesis, but the mechanism for this synergism is unknown. By using purified human erythroid colony-forming cells (ECFC), we have found that SCF and EPO synergistically activate MAP kinase (MAPK, ERK1/ 2), which correlates with the cell growth and thus may be responsible for the synergistic effects. Treatment ...

conclusions since the severity of the behavioral symptoms in the 6-ohda-induced model of parkinson disease reflects the degree of the lesion in substantia nigra (sn) dopaminergic neurons, it is suggested that using the combination had neuroprotective effects. the obtained data suggest a synergistic neuroprotective and antiparkinsonian effect for flu, glib and b com. at least, a part of this eff...

the present paper compares full kinetics mechanisms in numerical modelling of porous radiant burners (prb), with their reduced forms. the two most frequently used mechanisms of methane combustion (gri3.0 and miller) were selected and their effects were examined on temperature, species concentration, burning speed, and pollutant emission. while the findings of numerical simulation of prb show fi...

Synergistic cooperation of different enzymes is a prerequisite for efficient degradation of cellulose. The conventional mechanistic interpretation of the synergism between randomly acting endoglucanases (EGs) and chain end-specific processive cellobiohydrolases (CBHs) is that EG-generated new chain ends on cellulose surface serve as starting points for CBHs. Here we studied the hydrolysis of ba...

electric arc furnace dust (eafd) of ferromanganese production units, in the form of slurry, contains tar, alkalies, manganese, zinc, iron, silica, calcium, aluminum and other elements. a hydrometallurgical route based on solvent extraction technique was investigated for selective separation of manganese from the dust. leaching of the eafd resulted in an aqueous feed containing 4 g/l of manganes...

background: increasing worldwide contamination with hydrocarbons has urged environmental remediation using biological agents such as bacteria. our goal here was to study the phylogenetic relationship of two crude oil degrader bacteria and investigation of their ability to degrade hydrocarbons. materials and methods: phylogenetic relationship of isolates was determined using morphological and bi...

background and objectives: the selection of alternative treatment options with antibiotic combinations may be used for successful managing of multidrug-resistant acinetobacter baumannii . the aim of this study was to determine the synergistic effects of ampicillin-sulbactam combined with either levofloxacin or tigecycline against mdr a. baumannii. materials and methods: a total 124 of a.baumann...

Yoo J, Chung C, Slice L, Sinnett-Smith J, Rozengurt E. Protein kinase D mediates synergistic expression of COX-2 induced by TNFand bradykinin in human colonic myofibroblasts. Am J Physiol Cell Physiol 297: C1576–C1587, 2009. First published September 30, 2009; doi:10.1152/ajpcell.00184.2009.—Myofibroblasts have recently been identified as major mediators of tumor necrosis factor(TNF)-associated...

BACKGROUND Breathing the inert gas Xenon (Xe) enhances hypothermic (HT) neuroprotection after hypoxia-ischemia (HI) in small and large newborn animal models. The underlying mechanism of the enhancement is not yet fully understood, but the combined effect of Xe and HT could either be synergistic (larger than the two effects added) or simply additive. A previously published study, using unilatera...