Universitä t Freiburg with the analysis of folding of specific endogenous proteins in mutant strains, these studies have led to signifi-Hermann Herder Str. 7 D-79104 Freiburg cant advances in our understanding of protein folding in the complex cellular milieu. Germany Nascent chains emerging at the peptide exit tunnel of Madison, Wisconsin 53706 the ribosome are awaited by a welcoming committee...

A series of new barbituryl/thiobarbituryl substituted organomercurial derivatives 3a-i have been synthesised from pyrimidine derivatives 1a-c and arylmercuric chloride 2a-c over K(2)CO(3) under microwave irradiations (MWI). This solventless synthesis apart from eliminating organic solvent from workup step, also gave improved yield as compared to the conventional heating, with reaction time redu...

We revisit the interactive consistency problem introduced by Pease, Shostak and Lamport. We first show that their algorithm does not achieve interactive consistency if faults are transient, even if faults are non-malicious. We then present an algorithm that achieves interactive consistency in presence of nonmalicious, asymmetric and transient faults, but only under an additional guaranteed dela...

A databank for chemically synthesized genes has been compiled.

Reverse-correlation is the most widely used method for mapping receptive fields of early visual neurons. Wiener kernels of the neurons are calculated by cross-correlating the neuronal responses with a Gaussian white noise stimulus. However, Gaussian white noise is an inefficient stimulus for driving higher-level visual neurons. We show that if the stimulus is synthesized by a linear generative ...

We consider the task of assembling a large number of self controlled parts (or robots) into copies of a prescribed assembly (or formation). In particular, we describe a computationally tractable way to synthesize, from a specification of the desired assembly, local controllers to be used by each part, which when taken together, have the global effect of assembling the parts. We then prove that ...

Microalgae are microorganisms that have different morphological, physiological, and genetic traits that confer the ability to produce different biologically active metabolites. Microalgal biotechnology has become a subject of study for various fields, due to the varied bioproducts that can be obtained from these microorganisms. When microalgal cultivation processes are better understood, microa...

In this paper, an established method for microfluidic-directed formation of liposomes is combined with in-line sample purification and active drug loading for one-step, continuous flow synthesis of small, nearly monodisperse vesicles containing high concentrations of stably-loaded compounds. Through microfluidic buffer exchange, the presented technique demonstrates the ability to establish a ch...

We aimed to study the mechanisms and the significance of the influence exerted by the renin-angiotensin system (RAS) on the pineal melatonin production. Pineal melatonin and other indoles were determined by HPLC with electrochemical detection after angiotensin AT1-receptor blockade with Losartan in vivo or in cultured glands. N-acetyltransferase (NAT) activity was radiometricaly measured. To te...

To enable ultrahigh capacity laser communications in future networks, CONSRT is developing all-optical buffers, high-speed lasers, broadband optical amplifiers and memory devices to replace the speed-limiting optical-electrical-optical (OEO) switching system currently used in optic fiber communication. To date, realization of an all-optical communication network has been stymied by the lack of ...