Acid-sensing ion channels (ASICs) are ion channels activated by extracellular protons. They are involved in higher brain functions and perception of pain, taste, and mechanical stimuli. Homomeric ASIC1a is potently inhibited by the tarantula toxin psalmotoxin 1. The mechanism of this inhibition is unknown. Here we show that psalmotoxin 1 inhibits ASIC1a by a unique mechanism: the toxin increase...

Colon cancer (CRC) is one of the most common types in world. In this study, effects Tarantula cubensis alcoholic extract (TCAE) and Capecitabine CRC were investigated. Wistar albino rats divided into eight groups with 12 animals each group: untreated healthy groups, treated TCAE or Capecitabine, both Capecitabine. Azoxymethane was used all groups. administered to relevant starting 15th week. Al...

ABSTRACT We reassess the historical LX/LBol relation for early-type stars from a comparison between T-ReX, Chandra ACIS X-ray survey of Tarantula Nebula in Large Magellanic Cloud (LMC), and contemporary spectroscopic analysis massive obtained primarily VLT/FLAMES, VLT/MUSE, HST/STIS surveys. For 107 sources common (some host to multiple stars), majority which are bolometrically luminous (40 per...