Axin and conductin (also known as axin2) are structurally related inhibitors of Wnt/β-catenin signalling that promote degradation of β-catenin. Whereas axin is constitutively expressed, conductin is a Wnt target gene implicated in Wnt negative-feedback regulation. Here, we show that axin and conductin differ in their functional interaction with the upstream Wnt pathway component Dvl. Conductin ...

Testicular feminization, or the androgen insensitivity syndrome, is a rare disease. Because of various abnormalities of the X chromosome, a male, genetically XY, has some physical characteristics of a woman or a full female phenotype. Indeed the androgen insensitivity syndrome occurs because of a resistance to the actions of the androgen hormones, which in turn switches the development towards ...

Complex wavelet Packet modulation CWPM system has gained special interest as compared with traditional WPM due to its positive features like shift insensitivity, good directionality, and presence of phase information. The objective of this paper is to design a baseband π/4-DQPSK CWPM transceiver and implementing it on FPGA hardware. The design uses 8point Discrete Wavelet Packet Transform DWPT/...

When people are asked to assess or compare the value of experienced or hypothetical events, one of the most intriguing observations is their apparent insensitivity to event duration. The authors propose that duration insensitivity occurs when stimuli are evaluated in isolation because they typically lack comparison information. People should be able to evaluate the duration of stimuli in isolat...

A B S T R A C TIntroduction: Although decision-making processes have become a principal target of study among addiction researchers, few researches are published according to effects of different treatment methods on the cognitive processes underlying decision making up to now. Utilizing cognitive modeling method, in this paper we examine the effects of Methadone maintenance treatment (MMT) on ...

a b s t r a c tintroduction: although decision-making processes have become a principal target of study among addiction researchers, few researches are published according to effects of different treatment methods on the cognitive processes underlying decision making up to now. utilizing cognitive modeling method, in this paper we examine the effects of methadone maintenance treatment (mmt) on ...

Congenital insensitivity to pain with anhidrosis (CIPA) is a very rare hereditary syndrome worldwide due to certain gene mutations and histological appearances that affect the peripheral pathway of noxious stimuli transmission and the innervation of sweat glands. It is characterized by insensitivity to pain, anhidrosis, and heat intolerance. We describe the clinical features and the anaesthetic...