The standard of care for head and neck cancer typically includes surgical resection of the tumor followed by targeted head and neck radiation. However depending on tumor location and stage, some cases may not require surgical resection while others may be treated with chemoradiation. Unfortunately, these radiation treatments cause chronic negative side effects for patients. These side effects a...

Radiation therapy plays an important role in the management of a wide range of cancers. Besides innovations in the physical application of radiation dose, radiation therapy is likely to benefit from novel approaches exploiting differences in radiation response between normal and tumor cells. While ionizing radiation induces a variety of DNA lesions, including base damages and single-strand brea...

background: attenuation coefficient (μ) plays an important role in calculations of treatment planning systems, as well as determination of dose distributions in external beam therapy, dosimetry, protection, phantom materials and industry. so, its exact measurement or calculation is very important. the aim of this study was to evaluate the μ in different points in the water phantom analytically ...

introduction radiotherapy with small fields is used widely in newly developed techniques. additionally, dose calculation accuracy of treatment planning systems in small fields plays a crucial role in treatment outcome. in the present study, dose calculation accuracy of two commercial treatment planning systems was evaluated against monte carlo method. materials and methods siemens once or linea...

Until themid-1990s, postoperative adjuvant radiation therapy was considered the standard of care in management of operable rectal cancer (1). Although several investigators had demonstrated improvements in local recurrence rates, better options for sphincter preservation, improved survival, and lower toxicities, it was impossible to undertake and complete prospective studies of preoperative (ne...

An adaptive response may be defined as the effect of a small priming dose of radiation modifying the anticipated cellular response of the same tissues so as to alter the predicted response to a larger dose of radiation. We and others have demonstrated that at low radiation doses (less than 0.5 Gy) the lethal and mutational effect of the radiation is mainly, possibly entirely, due to the non-tar...

Castration-resistant prostate cancer is an incurable disease. To date, six agents-abiraterone, enzalutamide, docetaxel, cabazitaxel, radium-223 and sipuleucel-T- have shown clinical efficacy in phase III clinical trials, leading to their FDA approval. Patients are typically sequenced through most or all of these agents, and then eventually succumb to their disease. Development of new treatments...

introduction today, there is a growing interest in the use of hadrontherapy as an advanced radiotherapy technique. hadrontherapy is considered a promising tool for cancer treatment, given its high radiobiological effectiveness and high accuracy of dose deposition due to the physical properties of hadrons. however, new radiation modalities of dose delivery and on-line beam monitoring play crucia...

We report on experience and insights gained from prototyping, for clinical radiation oncologists, a new access tool for the University of Washington Digital Anatomist information resources. This access tool is designed to integrate with a radiation therapy planning (RTP) system in use in a clinical setting. We hypothesize that the needs of practitioners in a clinical setting are different from ...

There is an urgent need for new antimicrobial therapies to combat drug resistance, new pathogens, and the relative inefficacy of current therapy in compromised hosts. Ionizing radiation can kill microorganisms quickly and efficiently, but this modality has not been exploited as a therapeutic antimicrobial strategy. We have developed methods to target ionizing radiation to a fungal cell by label...