Alzheimer’s disease (AD) as a complicated and progressive neurodegenerative disorder is the most common form of dementia and memory loss. On account of the multifactorial etiology of AD, the multi-target-directed ligand (MTDL) approach is a promising method in searching new drug candidates for this disease. Here, in this paper more than 500 tacrine-coumarin hybrids have been designed and drug-l...

We prove the equality of doubly refined enumerations of Alternating Sign Matrices and of Totally Symmetric Self-Complementary Plane Partitions using integral formulae originating from certain solutions of the quantum Knizhnik– Zamolodchikov equation. The authors thank N. Kitanine for discussions, and J.-B. Zuber for a careful reading of the manuscript. PZJ was supported by EU Marie Curie Resear...

Seizure is the most common paediatric neurological disorder, with up to 10% of children having at least one attack of seizures during childhood. Despite the great expansion of seizure treatments in children in the recent years, many patients are refractory to medical treatment. The discovery of microRNAs (miRNAs) revolutionized the world of molecular biology. Extensive studies have suggested cr...

Cardiovascular diseases are gaining a dubious distinction of becoming the leading cause of death. Thus, the search for new risk markers and risk factors of cardiovascular disease continue, in an attempt to predict the risk of cardiovascular events with greater precision. Of all the risk markers available, high sensitivity C-reactive Protein (hsCRP) is considered to be the most robust tool with ...

Drug target identification is of significant commercial interest to pharmaceutical companies, and there is a vast amount of research done related to the topic of therapeutic target identification. Interdisciplinary research in this area involves both the biological network community and the graph algorithms community. Key steps of a typical therapeutic target identification problem include synt...

Introduction The recent advances in the management of juvenile idiopathic arthritis (JIA) have increased considerably the potential to achieve disease remission or, at least, low levels of disease activity, and have consequently moved the therapeutic aims towards the attainment of inactive disease (ID). Complete disease quiescence is regarded as the ideal therapeutic target because its achievem...

Kurzfassung. Ganzkörper-MRT findet im medizinischen Alltag immer mehr Anwendung in der Früherkennung und Ausbreitungsdiagnostik von Erkrankungen. Aufgrund eines erhöhten Rechenaufwandes bei bestimmten Aufnahmetechniken, wie beispielsweise dem Dixon Protokoll, kann die automatische Generierung der Ganzkörperdaten durch die Gerätekonsole nicht erfolgen, es werden nur die einzelnen Segmente gespei...

Students, educators, employers, and other stakeholders are concerned by the continued lengthening of time to attainment of the doctorate (TTD). A sequential quantitative-qualitative mixed research design was utilized in this study to understand what factors influence TTD. In the quantitative phase, discrete-time event history modeling was employed to analyze secondary data on 1,028 Education gr...

*Correspondence: Takeo Nomura, Department of Oncological Science (Urology), Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita 879-5593, Japan; Phone: 81975865893; Fax: 81975865899; e-mail: [email protected]

study on polsar target detection essentially requires the cattering information and polarimetric statistical data. theoretical analysis shows that some terms of the second order scattering matrices such as coherence and covariance matrix clearly show the differences between nonsymmetrical man-made objects and natural clatters which being reflection symmetric. using the model derived from these ...