OBJECTIVE To evaluate the usefulness of (99m)Tc-2-Methoxy-Isobutyl-Isonitrile Single Photon Emission Computed Tomography (MIBI-SPECT) for assessing anterior mediastinal mass, and distinguishing the grade of malignancy of thymic epithelial tumors to offer guidance for decision making. METHODS From January 2006 to November 2009, 31 consecutive patients with an anterior mediastinal mass at CT we...

UNLABELLED Preliminary findings have suggested that (99m)Tc-glucarate has tumor-seeking properties. The purpose of this study was to explore the potential of this tracer to evaluate malignant head and neck tumors by means of SPECT/CT software fusion imaging. METHODS Eleven male patients with advanced head and neck carcinoma were included in the study: 9 with locally advanced disease and 2 wit...

Despite recent advances in therapeutic and diagnostic approaches, coronary artery disease (CAD) and its related cardiac disorders represent the most common cause of death in the United States. Nuclear myocardial perfusion imaging (MPI) technologies play a pivotal role in the diagnosis and treatment design for CAD. Recently, in order to develop improved MPI agents for diagnosis of CAD, (99m)Tc-[...

OBJECTIVE Gastrointestinal motility and functional motility disorders causing either delayed or accelerated gastric emptying (GE) may result in similar symptoms including nausea, vomiting, early satiety, fullness, bloating, and abdominal discomfort or pain. Hence, it is important to evaluate patients for both rapid and delayed GE in the same test. The gold standard technique to measure GE is sc...

Introduction: Several radiotracers are being used for sentinel node mapping in patients with breast cancer. In the current study, we reported our experience with 99m-Tc Phytate for sentinel node mapping in Mashhad University of Medical Sciences. Methods: All breast cancer patients who underwent sentinel node mapping using 99m-Tc Phytate were included. All patients received intradermal peri-are...

Twenty-one patients with medullary thyroid carcinoma were studied prospectively with Tc-99m (V) DMSA after surgery. Pentavalent DMSA scintigram demonstrated abnormal uptake in 13 and equivocal uptake in 6 patients. Finally, seven patients with surgical or other imaging documentation were selected for this paper. Most of these patients were asymptomatic. Six patients had hypercalcitonemia ...

Abstract Hydroxamamide (Ham) is a thiol-free chelating agent that forms technetium-99m ( 99m Tc)-complexes with metal-to-ligand ratio of 1:2 under moderate reaction conditions. Therefore, Ham-based agents will produce Tc-labeled compounds bivalent targeting scaffold. For their universal usage, we developed novel bifunctional agent, “Ham-Mal”, maleimide group can easily conjugate thiol group, fo...

UNLABELLED Assessment of tumor viability and necrosis of non-small cell lung cancer and detection of distant metastases are important for diagnosis, staging, monitoring the response to treatment and planning long-term management. We performed scintigraphy on patients with non-small cell lung cancer to determine the utility of three tumor targeting tracers for diagnosing primary lung cancer, for...

introduction: in the current study, we evaluated the feasibility of body outlining using tc-99m filled flood source for lymphoscintigraphy imaging. methods: 80 patients were included in the study. sentinel node mapping was done using tc-99m antimony sulfide colloid. for outlining the body a tc-99m filled flood source was used which was placed behind or lateral to the patients for anterior and ...

Evaluation of Tc-99m red blood cell (RBC) SPECT in suspected hemangioma of the liver shows a high sensitivity and specificity when lesions are larger than 2 cm, and allows for the discrimination between hemangioma and other hepatic lesions. However, its major limitation arises with small size lesions. The accuracy of Tc-99m RBC SPECT in small suspected hemangiomas of the liver might improve the...