Access to point-of-care (POC), rapid, inexpensive, sensitive, and instrument-free tests for the diagnosis of tuberculosis (TB) remains a major challenge. Here, we report a simple and low-cost microchip-based TB ELISA (MTBE) platform for the detection of anti-mycobacterial IgG in plasma samples in less than 15 minutes. The MTBE employs a flow-less, magnet-actuated, bead-based ELISA for simultane...

Diffuse optical tomography (DOT) has been studied for use in the detection of breast cancer, cerebral oxygenation, and cognitive brain signals. As optical imaging studies have increased significantly, acquiring imaging data in real time has become increasingly important. We have developed frequency-division multiplexing (FDM) DOT systems to analyze their performance with respect to acquisition ...

Ever-growing textual data make it increasingly difficult to effectively utilize all the information relevant to our interests. For example, Medline—a comprehensive bibliographic database in life science—currently contains over 16 million articles, and the number is rising rapidly by 2,000–4,000 per day. Given the substantial volume of information, it is crucial to develop intelligent informatio...

Today’s researchers expect to be able complete text and data mining (TDM) work on many types of textual data. But they are often blocked more by contractual limitations what can use, how use it, than may available them. This article lays out the different TDM processes currently in issues that block from being do would like, some possible solutions.

Interference management for co-channel deployment of macro-cells and closed subscriber group (CSG) home-cells (HeNBs) are studied. We especially address the downlink macrolayer coverage-hole problem, where HeNBs may create too high interference to nearby macro-users, unless active interference management is applied. Interference management techniques based on HeNB power setting and partial Time...

Schizophrenia is a severe psychiatric disorder often associated with cognitive impairment and affective, mainly depressive, symptoms. Antipsychotic medication is the primary intervention for stabilization of acute psychotic episodes and prevention of recurrences and relapses in patients with schizophrenia. Typical antipsychotics, the older class of antipsychotic agents, are currently used much ...

In this paper, we propose the use of multilevel modulation formats with differential detection to enable Next-Generation Time-Division Multiplexing Passive Optical Networks (TDM-PONs). Bidirectional transmission of 30 Gb/s Differential 8 Phase-Shift Keying (D8PSK), on the downstream, and 10 Gb/s On-Off Keying (OOK), on the upstream, over a TDM-PON has been demonstrated experimentally. Furthermo...

Immune responses in major histocompatibility complex (MHC)-disparate congenic mouse strains immunized with sexual stage malaria parasites or purified recombinant protein were adjuvant dependent. Whereas mice exhibited a limited antibody response to immunization with newly emerged Plasmodium falciparum gametes in Freund's adjuvant, all five congenic mouse strains responded to several transmissio...