Breast cancer is the most common malignant tumor in women and a big challenge to clinical treatment due high morbidity mortality. The pH/ROS dual-responsive nanoplatforms may be an effective way significantly improve therapeutic efficacy of breast cancer. Herein, we report docetaxel (DTX)-loaded pH/ROS-responsive NP that could achieve active targeting cells selective complete drug release for d...

Biodistribution of nanoparticle-based intracellular delivery systems is mediated primarily by particle size and physicochemical properties. As such, overcoming the rapid removal of these by the reticuloendothelial system remains a significant challenge. To date, a number of copolymer nanoparticle systems based on 2-methacryloyloxyethyl phosphorylcholine (MPC) with 2-(diisopropylamino)ethyl meth...

The major challenge in cancer therapy is to efficiently translocate drug molecules into cancer tumors without doing any damage to healthy tissues. Since there exist pH gradients between tumor and normal tissues, pH-sensitive materials may have great potential to overcome such challenge. Here, we report one new type of pH-responsive drug delivery system where pH-sensitive polymers are introduced...

pH-responsive nanocarriers have the potential to provide targeted delivery of antimicrobial peptides (AMPs) sites bacterial infection with typically abnormal pH levels in body. However, local infected varies substantially among different infection-related diseases, calling for development systems capable targeting pathological conditions an adjustable range. In this study, a highly versatile na...

Acetalated dextran (Ac-DEX) is a pH-responsive derivative polymer. Ac-DEX and its functional derivatives have been formulated as nano- or microparticles for drug delivery applications in the biomedical field.

Solubilization of single-walled carbon nanotubes (SWNTs) using noncovalently interacting polymer surfactants in aqueous media has opened up a new vista of SWNTs in biology and medicine. In many potential applications, it is desirable to control the dispersion or aggregation of SWNTs in solvents with external stimuli. Here we report two "smart" SWNT dispersions that respond to temperature and pH...