I t is not possible for me to represent the high tradition of Josiah Willard Gibbs by offering you a mathematical treatment. Nevertheless, the subject of biological evolution and its mechanism must be of great interest to yourselves, as the most exemplary products of its operation. Perhaps, then, our reconnaissance flight over these biological jungles, and our attempts to measure certain aspect...

Pylorospasm and gastric retention in man have been regarded as important factors in the genesis of peptic ulcers (1) but the factors controlling pyloric function and gastric evacuation have continued to remain more or less obscure (2). Attempts to produce pylorospasm in dogs do not seem to have met with success (lb). Our own study of the subject began in an at tempt to determine whether the gas...

The current extensive programs on antitumor chemotherapeutic screening and drug evaluation are conducted mainly in rodents with transplantable tumors (7, l l , 13, 14, 19, ~4, ~6, 43, 45, 46, 48, 56, 57, 60-65, 67, 7~, 75, 78, 84-91, 94, 99). Additional programs are being conducted with spontaneous and carcinogen-induced tumors (1~, 48, 69, 79, 80, 96) and with tissue culture (8, 17, 18, ~1, ~ ...

Intranasal treatment with C57BL/6 MSCs reduces lesion volume and improves motor and cognitive behavior in the neonatal hypoxic-ischemic (HI) mouse model. In this study, we investigated the potential of human MSCs (hMSCs) to treat HI brain injury in the neonatal mouse. Assessing the regenerative capacity of hMSCs is crucial for translation of our knowledge to the clinic. We determined the neuror...

Let me confess at the outset that I feel uncomfortable with the title given to my presentation, "Selling Health to the Public," and that I feel equally uncomfortable with such terms as, "marketing health," "the health marketplace," or any others that equate the health area with the marketplace. These terms have become quite popular in recent years because the presumed success of Madison Avenue ...

This text, in both concept and execution, was an ambitious undertaking by its editors Peter S. Spencer and Herbert H. Schaumberg, who also serve as major contributors. To describe this work as over-ambitious would be to imply that it does not reach the rigorous goals it sets for itself. Happily, this reader can report that Experimental and Clin­ ical Neurotoxicology is, by and large, successful...

Inspite of the fact that the study of suicidal behaviour has been the subject of an ever increasing body of li terature, re catch in the field of communication of suicidal intent has somehow not received due attention. Quite often pntient 's suicidal ideas may remain unnoticed during clinical interview in an overcrowded psychiatric outpatient and at times this inadvertent neglect might result i...

Recent developments in genetic linkage mapping of the h uman genome have generated a large number of short tandem repeat polymorphic markers (13). Eventual integration of these markers into a-physical map is a natural and a necessary step. A large number of genomic clones have been generated for the early-onset breast and ovarian cancer (BRCA1) region at 17q21 (1-3, 5, 7, 9, 10) and are being u...

Myelin formation and its relation to the neuroglia has been a problem of continuing interest to neurocytologists since the early work of Jastrowitz (1), Boll (2), and Wlassak (3). I t was not until 1928, however, that del Rio-Hortega (4) ascribed to the oligodendroglia a definite role in the process of myelinization. Since then other workers (5, 6) have supported del Rio-Hortega's thesis, altho...

The volume has the feel of an intimate scrapbook of many of the key events and documents in Darwin’s life. But it is more than just a scrapbook: the words are written by science historian, John van Wyhe. A distinguished Darwin scholar at Cambridge University, van Wyhe is also director of the major project to make the entire work of the evolutionary biologist available electronically. Darwin Onl...