PURPOSE To investigate the anti-adhesive mechanisms of PXL01 in sodium hyaluronate (HA) by using the rabbit lactoferrin peptide, rabPXL01 in HA, in a rabbit model of healing tendons and tendon sheaths. The mechanism of action for PXL01 in HA is interesting since a recent clinical study of the human lactoferrin peptide PXL01 in HA administered around repaired tendons in the hand showed improved ...

Rotator cuff tendon tears are one of the most common shoulder injuries. Although surgical repair is typically beneficial, re-tearing of the tendons frequently occurs. It is generally accepted that healing is worse for chronic tears than acute tears, but the reasons for this are unknown. One potential cause may be the large tensions that are sometimes required to repair chronically torn tendons ...

contributions from the medial, lateral, and long heads of the muscle. During the course of performing a triceps tendon repair, we noted a specific deep tendon separate from the more superficial tendon. This observation stimulated us to perform an anatomical study to define the triceps tendon in greater detail. The purpose of this study is to better define the triceps brachii tendon and its inse...

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Posterosuperior repair of the rotator cuff is one of the most frequently performed surgical procedures in the shoulder. Its aim is to fix the tendon back to the bone to restore anatomy, improve shoulder function, and prevent progression of cuff tear arthropathy and attendant muscle degeneration. Despite technical advances in this procedure, in some cases, the tendon cannot be fixed back to the ...

Tendon injuries are very common in occupational and athletic settings, and the elderly population. Tendons repair and regenerate slowly and inefficiently in vivo after injury. The limited ability of tendons to self-repair and the general inefficiency of current treatment strategies have intensified the need for an effective therapeutic approach. Tendon-derived stem cells (TDSCs) have recently b...

BACKGROUND Cyclooxygenase-2 inhibitors inhibit bone repair. HYPOTHESIS Cyclooxygenase inhibitors might also have a negative effect on early tendon repair, although a positive effect on late tendon repair previously has been shown. STUDY DESIGN Controlled laboratory study. METHODS Achilles tendon transection was performed on 80 rats. Sixty rats were given daily intramuscular injections of ...

BACKGROUND There has been no published report assessing the mechanical properties of a repaired Achilles tendon after surgery using shear wave elastography (SWE). The aim of this study was to investigate the changes in mechanical properties of the healing Achilles tendon after surgical repair of a tendon rupture using ultrasound SWE and how these changes correlate with tendon function. MATERIAL...

BACKGROUND The objectives of the present study were to compare changes in muscle excursion, total collagen, and collagen subtypes after tenotomy over time and after delayed tendon repair. METHODS Tenotomy on the extensor digitorum tendon of the right second toes of 48 New Zealand White rabbits was performed; toes on the left leg were used as controls. Passive muscle excursion, total collagen ...

BACKGROUND Blood platelets release a cocktail of growth factors when activated, some of which are thought to initiate and stimulate repair. EXPERIMENT AND FINDINGS We studied whether a platelet concentrate injection would improve Achilles tendon repair in an established rat model. The Achilles tendon was transected and a 3 mm segment removed. After 6 h, a platelet concentrate was injected per...