It was reported that adenine causes fetal malformations with high frequency when 250 or 300 mkikg of the compound was injected I. p. (.intraperitoneally) to pregnant mice during major organogenesis (Fujii and Nishimura, 1970 Fujii, 1970). Chaube and Murphy (1969) administered the compound i. R. to female rats on day 12 of gestation at various dosages less than 250 mg/kg, but did not find .any e...

Background In the UK, simulation in midwifery education mostly relates to developing clinical skills such as managing obstetric emergencies. However, there is minimal use of neonate simulators educating student midwives on impact teratogens fetal development. There also limited research using neonatal a creative pedagogical tool undergraduate education. Objectives The two main objectives this s...

Inhibition of calcification in embryonic bone rudiments was studied in the presence of several tetracyclines at three different concentrations. Different criteria for calcification and different concentrations of tetracyclines yielded parallel results and showed significant differences in the inhibitory action of the various compounds. The clear-cut results indicate that the test-system that wa...

The availability of new antiepileptic drugs has broadened the spectrum of medical treatment options in epilepsy. The new agents, together with established drugs, offer substantial choice for doctors treating patients with focal or generalised epilepsy. The newer antiepileptic drugs are not necessarily more effective but usually better tolerated than the traditional agents, mainly because of fav...

This article puts into perspective the controversy between the association of the use of misoprostol for abortion and teratogenicity studies of the type found in a case report. The use of herbal medicinal drugs and the medical-obstetric and national and international norms governing the registration and circulation of pharmaceutical products were examined. Official documents of ANVISA, the Mini...

Teratogen-induced alterations in gene expression play an important role in the genesis of malformations in animals. The recent development of DNA microarrays now offers the opportunity to monitor global changes in gene expression and therefore the potential to obtain significant new information concerning both normal and abnormal development. RNA was isolated from day-9 mouse embryos at 1 and 5...