AIM The aim of this study was to investigate the impact of gestational age on energy metabolism in human umbilical vein endothelial cells (HUVECs) of preterm and term neonates. METHODS Activities of respiratory chain (RC) complexes I-V, citrate synthase (CS), overall mitochondrial fatty acid oxidation (FAO), carnitine palmitoyltransferase 2 (CPT2), glycolytic enzymes as well as energy-rich ph...

OBJECTIVE To evaluate the effect of high dose phenobarbital on lipid peroxidation and antioxidant enzymes in perinatal asphyxia. DESIGN Open label, Randomized controlled trial. SETTING Neonatal intensive care unit of a tertiary care teaching hospital. PARTICIPANTS 72 full term inborn neonates with severe birth asphyxia. METHODS Neonates were randomized to Study (phenobarbital) group and...

OBJECTIVE To compare the prevalence and clinical characteristics of neonatal abstinence syndrome in neonates exposed and not exposed to selective serotonin reuptake inhibitors (SSRIs) in utero. DESIGN Cohort study. SETTING Tertiary care center. Patients One hundred twenty term infants, of whom 60 had prolonged in utero exposure to SSRIs, including paroxetine hydrochloride, fluoxetine, cital...

Pre-dose and peak serum levels of gentamicin were measured in 82 neonates (25-42 weeks' gestational age), and for comparison in 10 infants and 9 children. Dosage was 2-2.5 mg/kg twice daily for the neonates, and three times daily for infants and children. Neonates were subdivided according to gestational age and weight. Serum levels of gentamicin were very variable in all groups. Preterm neonat...

Oxidative stress may play a central role in the onset of many diseases during the neonatal period. Malondialdehyde (MDA) is a marker of lipid peroxidation. The aim of this study was to evaluate a new marker, the malondialdehyde adduct to hemoglobin (MDA-Hb), which is measured in red blood cells (RBCs) and thus does not require that an additional blood sample be drawn. In this prospective study,...

Introduction: Pain in neonates is largely underestimated and neglected. Pain experience can alter clinical outcome, brain development and subsequent behavior in newborns. Numerous newborns undergo blood sampling routinely in nurseries/NICUs and these procedures are often done without pain relieving measures. Heel lancing and venepuncture are two common procedures for blood sampling in neonates....

Introduction: Resource limitation in developing countries may preclude access to cardiac troponin-T assay thereby necessitating reliance on clinical judgment for identification of hypoxic myocardial cellular injury. Objectives: To relate selected clinical signs with elevated serum cardiac troponin-T in asphyxiated term neonates. Methods: Asphyxia was identified by low umbilical arterial blood p...

Background: The readmission rate for neonatal jaundice has been increased in recent years. This has been attributed to shorter length of postpartum hospital stays without comprehensive follow-up. The purpose of this study was to determine the diagnostic value of pre-discharge transcutaneous bilirubin (TcB) levels for prediction of subsequent hyperbilirubinemia in healthy term neonates. Metho...

Background: Thrombocytopenia (TTP) is one of the most common neonatal hematological disorders. The causes of neonatal TTP are very various, leading to large differences in the clinical profile of the affected neonates. Therefore, the aim of this study was to investigate the characteristics, clinical diagnoses and short-term outcomes of neonatal TTP in Bahrami Children's Hospital. Material and ...

Background:Jaundice is an important problem in the 1 st week of life affecting approximately 60% of term and 80% of preterm infants. It is commonly managed by phototherapy. Phototherapy may result in the development of hypocalcemia & create serious complications including seizures & other condition. Objective:To study the effect of phototherapy on serum calcium is neonatal hyperbilirubiniea. De...