Human telomeric regions are packaged as constitutive heterochromatin, characterized by extensive subtelomeric DNA methylation and specific histone modifications. ICF (immunodeficiency, centromeric instability, facial anomalies) type I patients carry mutations in DNA methyltransferase 3B (DNMT3B) that methylates de novo repetitive sequences during early embryonic development. ICF type I patient ...

BACKGROUND Members of the Dmrt family, generally associated with sex determination, were shown to be involved in several other functions during embryonic development. Dmrt2 has been studied in the context of zebrafish development where, due to a duplication event, two paralog genes dmrt2a and dmrt2b are present. Both zebrafish dmrt2a/terra and dmrt2b are important to regulate left-right pattern...

In human somatic cells or yeast cells lacking telomerase, telomeres are shortened upon each cell division. This gradual shortening of telomeres eventually leads to senescence. However, a small population of telomerase-deficient cells can survive by bypassing senescence through the activation of alternative recombination pathways to maintain their telomeres. Although genes involved in telomere r...

The intestinal mucosa protects the body from a large reservoir of intraluminal pathogenic bacteria and endotoxins. This mucosal barrier is disrupted by the inflammation and ulceration of inflammatory bowel disease and may permit the absorption of toxic bacterial products. Systemic endotoxaemia has been demonstrated in ulcerative colitis and Crohn's disease and correlates with the extent and act...

Oil fields can experience souring, the reduction of sulfate to sulfide by sulfate-reducing microorganisms. At the Terra Nova oil field near Canada's east coast, with a reservoir temperature of 95°C, souring was indicated by increased hydrogen sulfide in produced waters (PW). Microbial community analysis by 16S rRNA gene sequencing showed the hyperthermophilic sulfate-reducing archaeon Archaeogl...

The Moderate Resolution Imaging Spectroradiometer (MODIS), onboard the NASA Terra and Aqua Earth Observing System satellites, provides multiple land surface temperature (LST) products on a daily basis. However, these products have not been adequately validated. This paper presents preliminary results of validating two MODIS Terra daily LST products, MOD11_L2 (version 4) and MOD07_L2 (version 4)...

Çatalca, located on the ridge between the Marmara and the Black Sea, is a rural district of Istanbul having the temperate climate. Landuse involves farming and forestry. This study makes a contribution and revises the applicability of two medium spatial resolution satellite sensors, NOAA AVHRR NDVI and MODIS (Terra) NDVI, for prediction to potential forest resource management in Çatalca distric...