Patients with sickle cell disease (SCD), especially males, face a key problem in the form of infertility. Apart from low serum testosterone, abnormalities involving accessory sex organs are also observed in these patients. Infertility is a known complication among males with SCD, and it comes about due to reasons such as impotence, relative primary gonadal failure, priapism, and delayed or impa...

Formalin is widely used in industry and in medicine (as tissue fixative and disinfectant).It contains reactive molecules which have been known for its cytotoxic effects. To evaluate the effect of formalin exposure on the testicular tissue and sperm parameter from neonatal period through physical and sexual maturity, 28 male Wister rats were assigned into two equal test and control groups. The t...

Varicocele is the most common diagnosis in men presenting to fertility clinics. Traditional indications for correction of varicocele include scrotal pain, testicular atrophy, and infertility without other apparent causes. Adolescent varicocele correction is indicated if pain or testicular growth retardation is present. Following varicocelectomy most studies report improved semen parameters, inc...

Uncertainty exists about the effect of antiepileptic drugs on gonadal function. In females, long-term valproate treatment has been shown to induce endocrine disturbances and an increased number of ovarian cysts. The aim of the present study was to investigate whether valproate can also induce morphological changes in the testis of male animals. In addition, possible morphological changes in the...

objective a 4-month-old female with osteogenesis imperfecta (oi) type ii was admitted in picu of our center due to severe respiratory distress and fever with a diagnosis of severe pneumonia, and mechanical ventilation was initiated. due to severe hypotonia, ncv and emg were performed, and spinal muscular atrophy (sma) type i was diagnosed.

Kuriyama, Y . (1972) J. Biol. Chem. 247,2979-2988 Nilsson, R., Peterson, E. & Dallner, G. (1973) J. CeN Biol. 56, 762-776 Pogell, B. M. & Leloir, L. F. (1961) J . Biol. Chem. 236, 293-298 Vessey, D. A. 8c Zakim, D. (1974) Biochem. J. 139,243-249 Winsnes, A. (1969) Biochim. Biophys. Acta 191,279-291 Winsnes, A. (1971) Biochim. Biophys. Acta 242, 549-559 Winsnes, A. (1972a) Biochim. Biophys. Acta...

The underlying reasons for the increasing occurrence of male reproductive diseases (MRD) such as hypospadias, cryptorchidism, and testicular cancer (TC) over the last decades are still unknown. It has been hypothesized that the risk of MRD is determined in utero and that pregnancy dietary intake could also affect MRD risk in the offspring. Various studies in animals reported that cocoa and theo...

BACKGROUND The exact pathophysiology of testicular degeneration, following varicocele has not been completely understood yet. OBJECTIVE The current study was designed to determine the effect of varicocele on germinal epithelium (GE) cytoplasmic biohistochmical alterations. MATERIALS AND METHODS To follow-up this study, left varicocele was induced in test groups. Non-varicocelized rats were ...