BACKGROUND Diazinon (DZN) is an organophosphate pesticide that widely used for agricultural pest control all over the world. DZN affects target organs including reproductive system by inhibiting the activity of acetylcholinesterase and inducing oxidative stress. Vitamin E (α-tocopherol) is a strong antioxidant which inhibits free radicals, and probably can reduce lipid perxidation effectively i...

background: this study examined the effect of grape seed proanthocyanidin extract (gspe) on lipid peroxidation content and activity of tissue antioxidant enzymes, including catalase, superoxide dismutase and glutathione peroxidase in diabetic rats. methods: thirty male rats were divided into three groups of 10 rats each: control, diabetic and diabetic groups that received 500 mg/kg gspe for 6 w...

this study was conducted on two canola (brassica napus) cultivars, okapi a winter type and cold tolerant and rgs003 a spring type and cold sensitive. seedlings were grown in an environmentally controlled growth room with 16 h d-1 photoperiod at 22/16 °c (day/night, control). at the 4-leaf stage, half of pots were transferred to a cold growth room for 7 d at 10/3°c (day/night, cold treatment) an...

Pathological conditions that predispose to cardiovascular events, such as hypertension, hypercholesterolemia, and diabetes, are associated with oxidative stress. These observations and further data derived from a plethora of investigations provided accumulating evidence that oxidative stress is decisively involved in the pathogenesis of endothelial dysfunction and atherosclerosis. Several enzym...

BACKGROUND In our previous study, significantly higher antioxidant enzymes and malondialdehyde (MDA) levels in patients with premature ejaculation (PE) compared to healthy controls were found. In the present study, we planned to evaluate antioxidant enzymes and MDA levels of patients with PE before and after citalopram treatment. METHODS The study comprised 30 patients with PE according to Di...

PURPOSE To evaluate the protective role of dimethylsulfoxide (DMSO) in a rat model of testis ischemia/reperfusion (I/R). METHODS Twenty-four male Wistar rats were randomized in two equal groups. Control rats (G-1) received saline 2.0 ml intraperitoneally (ip) 21, 9 and 1 h before torsion. Experimental rats (G-2) received ip injections of 3% aqueous solution of DMSO, 0.1ml/10g body weight. Sal...

INTRODUCTION A major activity at glutamatergic synapses in the brain is the production of potentially toxic oxygen radicals, in particular superoxide, by postsynaptic enzymes such as PGH synthase and by mitochondria. These need antioxidant mechanisms, such as the local production of antioxidant molecules (such as glutathione and ascorbate) and antioxidant enzymes, for protection of the neuron a...

background: prescription of antioxidants might increase the quality of sperm parameters and improve the rate of pregnancy in obese people who suffer from infertility. therefore, the present study investigated protective effects of vitamin a, e and astaxanthin on sperm parameters and seminiferous tubules epithelium in high-fat diet model. methods: thirty-six numbers of 3 months old albino wistar...

An extract of fermented wheat germ (EFWG) was prepared by treatment with Aspergillus oryzae and in vitro antioxidant and cellular antioxidant capacities were measured. The induction of phase II detoxifying and antioxidant enzymes in exerting a cellular antioxidant capacity was determined. Treatment of wheat germ with A. oryzae significantly (p<0.001) increased the ferulic acid content, compared...