Background and Aim: The aim of this study was to investigate the protective effects of Tanacetum parthenium extract (TPE) on lipid peroxidation and acute heart injury induced by carbon tetrachloride (CCl4) in rats. Materials and Methods: In an experimental study, 30 male Wistar rats were divided into 5 groups (n=6). Two of the groups were normal and damage control groups, other 3 groups were d...

Background: Various investigations have established that carbon tetrachloride (CCl4), a clear, colourless, volatile, heavy and nonflammable liquid, causes generation of free radicals in many tissues such as testis. a wide range of side effects such as reproductive toxicity has been observed following the administration of this liquid in experimental animals. Numerous studies have shown that amo...

objective(s): the objective of this study was to investigate the hepatoprotective effect of licochalcone b (lcb) in a mice model of carbon tetrachloride (ccl4)-induced liver toxicity. materials and methods: hepatotoxicity was induced in mice by a single subcutaneous injection (sc) of ccl4. the lcb was administered orally once a day for seven days (po) as pretreatment at three doses of 1, 5, and...

The ethanol and aqueous extracts of leaves of Neptunia Oleracea lour (Mimosaceae) were tested for their efficacy against carbon tetrachloride (CCl4) induced hepatotoxicity in Wistar albino rats. The different groups of animals were administered ethanol and aqueous extracts to carbon tetrachloride treated rats. In the present study ethanol extract (p<0.01) and aqueous extract (p<0.05) significan...

Aim: The aim of the present study was to evaluate the effect of Boerhaviadiffusa extract against carbon tetrachloride (CCl4) – induced lipid peroxidation in liver of mice in vitro. Methods: Antioxidant activity of medicinally important plant Boerhaviadiffusawas determined by DPPH – radical scavenging activity. Liver homogenates were prepared and used for various treatments (CCl4 and Boerhaviadi...

Carbon tetrachloride, even in very large doses, has been shownby Lamson et al. (1) to produce no acute intoxication in dogs on a well balanced mixed diet. A preliminary note from this labortory (2) reported, however, that similar or even very small doses of the drug caused a severe and usually fatal poisoning in dogs on a diet of lean meat without bones. One radical difference in the two diets ...

OBJECTIVE To study the carbon tetrachloride-induced hepatoprotective activity in cow urine. METHODS Effect of cow urine distillate on liver function was studied in vivo in rats intoxicated with carbon tetrachloride (CCl4). Hepatotoxicity was induced by a 1:1 (v/v) mixture of CCl4 in olive oil (5 mL/kg i.p). Protective effect of cow urine distillate (in three dose levels) and standard drug Sil...