OBJECTIVE To study the possible effect of tetracycline on protease-resistant activity in vitro and infectivity in vivo of a scrapie strain 263K. METHODS Scrapie pathogens were incubated with tetracycline at different concentrations for various periods of time and protease-resistant PrP signals were evaluated with proteinase K-treatment and Western blots. The preparations treated with tetracyc...

Objectives. To compare the effects of intra-articular application of statin and tetracyclines on cartilage and synovial tissue on experimental osteoarthritis. Methods. Osteoarthritis was created in 30 rabbits of 3 groups. The control group received saline intra-articularly, statin group, atorvastatin and the tetracycline group, doxycycline once a week for 3 weeks. Chondral and synovial tissues ...

An aerosol-induced staphylococcal infection of previously non-infected guinea pigs is described. Investigations concerning the dynamics of this infection indicate that: 1. An infection ("carrier state") could be established predictably in every animal exposed to the aerosol inoculum. 2. Infection was limited to the upper respiratory tract and occurred without apparent systemic dissemination. 3....

Hypertens ion: Diltiazem HCl CD produces its antihypertensive effect primarily by relaxation of vascular smooth muscle and the resultant decrease in peripheral vascular resistance. The magnitude of blood pressure reduction is related to the degree of hypertension; thus hypertensive individuals experience an antihypertensive effect, whereas there is only a modest fall in blood pressure in normot...

Hairy cell leukemia (HCL) is characterized by underexpression of the intracellular signaling molecule RhoH. Reconstitution of RhoH expression limits HCL pathogenesis in a mouse model, indicating this could represent a new therapeutic strategy. However, while RhoH reconstitution is theoretically possible as a therapy, it is technically immensely challenging as an appropriately functional RhoH pr...

DISEASE OVERVIEW Hairy cell leukemia (HCL) and HCL-like disorders, including HCL variant (HCL-V) and splenic diffuse red pulp lymphoma (SDRPL), are a very heterogeneous group of mature lymphoid B-cell disorders, characterized by the identification of hairy cells, a specific genetic profile, a different clinical course and the need for appropriate treatment. DIAGNOSIS Diagnosis of HCL is based...

background: shigella spp. are gram negative bacteria, which are of global public health importance. the growing of multidrug-resistant shigella isolates are a major problemaround the world. methods: overall, 50 isolates of shigella spp. from children diarrheic stools were studied. the isolates were identified and confirmed using biochemical, serological and molecular methods (ipah, wbgz and rfc...

this study investigated the photocatalytic behaviors for the nanocomposite of tio2 p25 and semnan natural zeolite in the decomposition of tetracycline under visible light in an aqueous solution. the structural features of the composite were investigated by a series of complementary techniques that included x-ray diffractometer (xrd), fourier transform infrared spectroscopy (ftir), scanning elec...

conclusion these data show that the identified gene encoded tet resistance gene as mfs–type multi-substrate efflux transporter, which contributes to intrinsic resistance on range of structurally unrelated compounds in salmonella species. background tetracyclines (tcs) are a type of broad-spectrum bacteriostatic antibiotics used for treatment of a wide variety of infections. these antibiotics ev...