The betaine/GABA transporter 1 (BGT1) is one of the four GABA transporter (GAT) subtypes that have been cloned from the mammalian brain. While its cerebral expression is well documented, its physiological function and therapeutic potential are poorly understood and subject to controversy. This is partly a result of the lack of pharmacological tools of sufficient potency and subtypeselectivity. ...

G protein-coupled receptors (GPCRs) are one of the most important classes of proteins in the genome, not only because of their tremendous molecular diversity but because they are the targets of nearly 50% of current pharmacotherapeutics. The majority of these drugs affect GPCR activity by binding to a similar molecular site as the endogenous cognate ligand for the receptor. These “orthosterical...

Open AccessCCS ChemistryRESEARCH ARTICLE14 Jul 2022In Situ Generation of N-Heteroaromatic Polymers: Metal-Free Multicomponent Polymerization for Photopatterning, Morphological Imaging, and Cr(VI) Sensing Yubing Hu, Neng Yan, Xiaolin Liu, Lingyu Pei, Canbin Ye, Wen-Xiong Wang, Jacky W. Y. Lam Ben Zhong Tang Hu Department Chemistry, The Hong Kong Branch Chinese National Engineering Research Cente...