Fetal in situ cardiovascular and bronchial morphologies were studied in rats with tetralogy of Fallot and absent pulmonary valve to clarify the prenatal pathology of this complex. There were 42 fetal rats with this complex among 300 fetuses treated with N,N'-bis-(dichloroacetyl)-1,8-octamethylenediamine (bis-diamine) (200 mg) on the 10th day of pregnancy. After undergoing rapid whole-body freez...

BACKGROUND Inflammatory reaction can produce several complications after cardiac surgery. Many attempts have been made to reduce these complications; perioperative corticosteroid therapy is one of the simplest methods. OBJECTIVES We conducted a randomized study to evaluate the efficacy of single dose methylprednisolone, prescribed after surgery, for reducing the complications. Repair of Tetra...

OBJECTIVE To assess right ventricular diastolic function in the intermediate postoperative period of repair of tetralogy of Fallot. METHODS We carried out a case-control study with 60 patients divided into 2 groups as follows: 1) group I - 30 patients who had undergone repair of tetralogy of Fallot and 2) group II - 30 healthy children. The 2 groups were paired for age, sex, and body surface....

OBJECTIVE To determine coronary artery anomalies in tetralogy of Fallot in Pakistani children as seen on angiography. STUDY DESIGN Case series. PLACE AND DURATION OF STUDY The National Institute of Cardiovascular Diseases, Karachi, Pakistan from July 2006 to July 2007. METHODOLOGY Children under 15 years of age with echocardiographic diagnosis of tetralogy of Fallot were included in the s...

OBJECTIVE To determine the prognostic significance of ventricular late potentials and spontaneous ventricular arrhythmias detected early after surgical repair of tetralogy of Fallot. DESIGN Prospective observational. SETTING Cardiology department of a teaching hospital. METHODS Between June 1984 and June 1991, 104 children (63 boys, 41 girls) were studied by signal averaging and 24 hour a...

Plasma renin activity and one-dimensional echocardiographic measurements of the left atrium and left ventricle as well as function indices were studied repeatedly in 20 children with various cardiopathies (ages: 9 months to 15 years) before and after corrective surgery. Nine children had tetralogy of Fallot, four had pulmonary stenosis, four had rheumatic heart disease, two had ventricular sept...

OBJECTIVE To identify any possible association between different readily available non-invasive indices and potential malignant ventricular arrhythmias in patients with repaired tetralogy of Fallot. DESIGN 27 consecutive patients, mean (SD) age 27.3 (11.7) years, were studied 15.7 (6.7) years after corrective surgery for tetralogy of Fallot, using 12 lead ECG, 24 hour Holter recordings, signa...

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The considerable body of clinical and physiologic data in patients with the tetralogy of Fallot that has been accumulated over the past 15 years now indicates that the original concept of the lesion as a single, fairly narrowly limited entity is no longer valid. The tetralogy can now be demonstrated to occupy a broad spectrum in the field of congenital cardiac anomalies, representing widely var...