نتایج جستجو برای: tgf β receptor 1 tgβri kinase inhibitor

تعداد نتایج: 3452671  

2013
Weipeng Xiong S. Courtney Frasch Stacey M. Thomas Donna L. Bratton Peter M. Henson

BACKGROUND/OBJECTIVE Phosphatidylserine (PS) exposed on apoptotic cells has been shown to stimulate production of transforming growth factor-β (TGF-β) and promote anti-inflammatory responses. However, the PS receptor(s) responsible for this induction has not been clearly determined. METHODOLOGY/PRINCIPAL FINDINGS In the present study, using RAWTβRII cells in which a truncated dominant negativ...

2013
Kyung Song Eswar Shankar Jiayi Yang Kara L. Bane Reema Wahdan-Alaswad David Danielpour

Survivin is a unique member of the inhibitor of apoptosis (IAP) proteins that is overexpressed in numerous cancers through poorly defined mechanisms. One such mechanism may be through constitutive activation of the insulin-like growth factor-I (IGF-I) signaling pathway, implicated in the development and progression of prostate cancer. Using the pre-neoplastic NRP-152 rat prostate cell line as a...

Journal: :Journal of immunology 2011
Francis Bonnefoy Mélanie Couturier Amandine Clauzon Jean-Paul Rémy-Martin Béatrice Gaugler Pierre Tiberghien Wanjun Chen Philippe Saas Sylvain Perruche

TGF-β is required for both Foxp3(+) regulatory T cell (Treg) and Th17 commitment. Plasmacytoid DCs (pDC) have been shown to participate to both Treg and Th17 commitment as well. However, few studies have evaluated the direct effect of TGF-β on pDC, and to our knowledge, no study has assessed the capacity of TGF-β-exposed pDC to polarize naive CD4(+) T cells. In this paper, we show that TGF-β-tr...

2012
Jianmei Gu Hui Qian Li Shen Xu Zhang Wei Zhu Ling Huang Yongmin Yan Fei Mao Chonghui Zhao Yunyan Shi Wenrong Xu

BACKGROUND Mesenchymal stem cells (MSCs) promote tumor growth by differentiating into carcinoma-associated fibroblasts (CAFs) and composing the tumor microenvironment. However, the mechanisms responsible for the transition of MSCs to CAFs are not well understood. Exosomes regulate cellular activities by mediating cell-cell communication. In this study, we aimed to investigate whether cancer cel...

2015
Wei He Jian Zhang Tian-yi Gan Guo-jun Xu Bao-peng Tang

In the present study, we examined the advanced glycation end products- (AGEs-) induced endothelial-to-mesenchymal transition (EndMT) in human umbilical vein endothelial cells (HUVECs). Results demonstrated that AGE-BSAs significantly reduced the cluster of differentiation 31 (CD 31) expression, whereas they promoted the expression of fibroblast-specific protein-1 (FSP-1), α-smooth muscle antibo...

2015
Stephan Herbertz J Scott Sawyer Anja J Stauber Ivelina Gueorguieva Kyla E Driscoll Shawn T Estrem Ann L Cleverly Durisala Desaiah Susan C Guba Karim A Benhadji Christopher A Slapak Michael M Lahn

Transforming growth factor-beta (TGF-β) signaling regulates a wide range of biological processes. TGF-β plays an important role in tumorigenesis and contributes to the hallmarks of cancer, including tumor proliferation, invasion and metastasis, inflammation, angiogenesis, and escape of immune surveillance. There are several pharmacological approaches to block TGF-β signaling, such as monoclonal...

2018
Yuanyuan Zhao Jing Ma Yanling Fan Zhiyong Wang Ran Tian Wei Ji Fei Zhang Ruifang Niu

Transforming growth factor-beta (TGF-β) functions as a potent proliferation inhibitor and apoptosis inducer in the early stages of breast cancer, yet promotes cancer aggressiveness in the advanced stages. The dual effect of TGF-β on cancer development is known as TGF-β paradox, and the remarkable functional conversion of TGF-β is a pivotal and controversial phenomenon that has been widely inves...

2011
Enrico Conte Mary Fruciano Evelina Fagone Elisa Gili Filippo Caraci Maria Iemmolo Nunzio Crimi Carlo Vancheri

Idiopathic pulmonary fibrosis (IPF) is a progressive fibroproliferative disease characterized by an accumulation of fibroblasts and myofibroblasts in the alveolar wall. Even though the pathogenesis of this fatal disorder remains unclear, transforming growth factor-β (TGF-β)-induced differentiation and proliferation of myofibroblasts is recognized as a primary event. The molecular pathways invol...

2016
WAN-NING WANG WEN-LONG ZHANG GUANG-YU ZHOU FU-ZHE MA TAO SUN SEN-SEN SU ZHONG-GAO XU

In this study, we aimed to explore the molecular mechanisms of and genetic factors influencing diabetic nephropathy (DN). Gene expression profiles associated with DN were obtained from the GEO database (Accession no. GSE20844). The differentially expressed genes (DEGs) between diabetic mice and non-diabetic mice were screened. Subsequently, the DEGs were subjected to functional and pathway anal...

Journal: :The Biochemical journal 1996
F L Hall P D Benya S R Padilla D Carbonaro-Hall R Williams S Buckley D Warburton

The transforming growth factor beta (TGF-beta) family of growth factors control proliferation, extracellular matrix synthesis and/ or differentiation in a wide variety of cells. However, the molecular mechanisms governing ligand binding, receptor oligomerization and signal transduction remain incompletely understood. In this study, we utilized a set of antibodies selective for the extracellular...

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